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Application of epimedium brevicornum glycosides in preparing medicament for treating senile dementia and product thereof

A technology for icariin and senile dementia, which is applied in drug combination, drug delivery, medical preparations containing active ingredients, etc., and can solve problems such as unsatisfactory effects

Inactive Publication Date: 2008-02-27
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The invention patent application with application number 200510094412.7 discloses a drug for preventing and treating Alzheimer's disease and its preparation. effect, but not ideal

Method used

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Effect test

Embodiment 1

[0397] Embodiment 1 of the present invention: Extraction of icariin: After the whole plant of dried Epimedium is pulverized, pass through a 60-80 mesh sieve, and extract 3 times with 75% industrial ethanol under reflux, each time for 2 hours, filter, and combine Extract the solution, recover the solution until it has no alcohol smell; add an appropriate amount of water, extract 3 times with an equal volume of chloroform, and extract the mother liquor 3 times with an equal volume of n-butanol, combine the n-butanol extracts and recover to obtain an extract; the extract is passed through silica gel Column chromatography, using chloroform-methanol = 5:1 as the eluent for separation, and then recrystallization to obtain the monomer compound icariin.

Embodiment 2

[0398] Embodiment 2 of the present invention: get 200 mg of icariin, 0.25 mg of magnesium stearate, 8 mg of sodium carboxymethyl starch, and 80 mg of microcrystalline cellulose, mix icariin with sodium carboxymethyl starch, microcrystalline cellulose Mix crystal cellulose, sieve, make it evenly mixed, add appropriate amount of water or ethanol to make granules, after drying, granulate, add magnesium stearate, and then press the granules into tablets with a punching device, and the tablet for treating senile dementia can be obtained agent.

Embodiment 3

[0399] Embodiment 3 of the present invention: get 200 mg of icariin, 0.20 mg of magnesium stearate, 8 mg of sodium carboxymethyl starch, and 80 mg of starch, mix icariin, sodium carboxymethyl starch, and starch evenly, Add appropriate amount of ethanol to granulate, dry, granulate, add magnesium stearate, and then pack into gelatin capsules to obtain capsules for treating senile dementia.

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Abstract

The invention discloses an application and product of icariin in the drug to treat senile dementia, which is characterized by the following: extracting icariin from berbere epimedium plant as flavonol compound; adopting icariin as raw material to prepare the monoclinic agent with simple technique and low cost; fitting for treating senile dementia with obvious effect and little side effect.

Description

Technical field: [0001] The invention relates to the application and product of icariin in the preparation of medicine for treating senile dementia, and belongs to the technical field of traditional Chinese medicine pharmacy. Background technique: [0002] Dementia is also known as Alzheimer's disease. At present, my country has entered an aging society, with an annual increase of 6 million elderly people. With the continuous improvement of the number and proportion of the elderly population, the incidence of dementia is also increasing year by year. According to incomplete statistics, the rate of people over 65 years old suffering from severe senile dementia is more than 5%, and by the age of 80, this rate will rise to 15-20%. The average survival period of senile dementia patients is 5.5 years, making this disease one of the main fatal diseases of the elderly in modern society. With the prolongation of human life and the increasingly prominent problem of social aging, t...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/00A61K9/20A61K9/48A61K47/38A61P25/28A61K36/296
Inventor 石京山
Owner ZUNYI MEDICAL UNIVERSITY
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