Modified producing method for trichlorosaccharose

A technology for sucralose and a production method, which is applied to the preparation of sugar derivatives, sugar derivatives, and sugar derivatives, etc., can solve the problems of high discharge of three wastes, low reaction density, unstable yield and quality, etc., and achieves a recovery rate. Increases, Reaction Steps, and Consumption Reduction Effects

Inactive Publication Date: 2008-02-20
清远天基谷醣实业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The reaction density is low, it needs to consume a lot of solvents with high boiling point, easy to decompose and difficult to recover, discharges a...

Method used

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  • Modified producing method for trichlorosaccharose
  • Modified producing method for trichlorosaccharose
  • Modified producing method for trichlorosaccharose

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no. 1 Embodiment

[0017] In the first specific embodiment of the present invention, a kind of primary hydroxyl group of sucrose is etherified with mono-p-methoxytriphenylchloromethane and acetylated. In a 1000 ml three-necked flask, 40 grams of sucrose powder (0.116mol) are added successively. and 180 milliliters of dimethylformamide, the temperature was raised to 45° C. to completely dissolve the sucrose, and 48 grams of N-methylmorpholine (0.572 mol) was added. Add 130 g of monomethoxytriphenylchloromethane (0.404 mol) within 3 hours, and react at constant temperature for 8 hours.

[0018] Add 34.4 g of sodium bicarbonate (0.41 mol) for neutralization. The reaction mixture was evaporated under vacuum to remove N-methylmorpholine, water and dimethylformamide. After the residue was dissolved in 80 ml of acetic anhydride (0.82 mol), 13 g of potassium acetate was added as a catalyst (0.132 mol) for acetylation. After cooling down slightly, the reaction mixture was poured into ice water with con...

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Abstract

An improved production method of sucralose is characterized by comprising the steps: (1) methoxy on benzene ring is used for replacing the three ortho-hydroxide radical of 6, 1' and 6' in trityl chloride etherified sucrose molecules and acylation reaction is carried out to prepare 6, 1', 6'-trimethoxy benzyl-penta acetic sucrose through etherealization and fine purification; (2) etherealization and acyl removal reactions are carried out to the 6, 1', 6'-trimethoxy benzyl-penta acetic sucrose in water-bearing weak acid at the same time, product 6-PAS generated from the reaction is refined and enters into the next chlorination reaction step; (3) 4, 1', 6'- trichloro-4, 1', 6'-trideoxidation galacto-sucrose (namely the sucralose) is prepared through the chlorination and acyl reaction of the 6-PAS. The invention combines the advantages of a full protective line and a single protective line, spurns the defects of the existing production methods and changes the original 'five steps' of the full protective line into 'four steps', thereby promoting the recovery rate of the full protective line greatly with less reaction steps and consumption, thus resulting in a more economic and environment protective production technology compared with the traditional production technologies of the full protective line or the single protective line.

Description

technical field [0001] The invention relates to a production method of 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose. Background technique [0002] 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose (i.e. sucralose, Sucralose) is a new type of strong sweetener, its characteristics are: high sweetness , which is 600 times sweeter than sucrose; pure sweetness, the taste is basically the same as sucrose; stable performance, not easily damaged by acid, alkali, high temperature and other harsh environments; wide application, can be used in almost all foods; as a sweetener in food It is safe to use in middle school; low in calories, non-rodent, suitable for diabetics and dental patients. [0003] There are 8 hydroxyl groups in the molecular structure of sucrose, selectively replacing the 4, 1', 6' hydroxyl groups in the sucrose molecule with chlorine atoms is the basic principle of making sucralose. If all other hydroxyl groups in the sucrose molecule except the 4, 1' and 6 hyd...

Claims

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Application Information

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IPC IPC(8): C07H5/02C07H1/00
Inventor 林洪周若愚杨顺
Owner 清远天基谷醣实业有限公司
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