Bone-repairing material and preparing method thereof

A technology for bone repair and raw materials, applied in the field of bone repair materials and their preparation, can solve the problems of local tuberculosis foci abscess recurrence, shortening the course of anti-tuberculosis drugs, lack of administration methods, etc., and achieves reduction of local abscess recurrence and sustained osteogenesis ability. , good biocompatibility and bioabsorbability

Inactive Publication Date: 2008-02-13
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For the current bone and joint tuberculosis, especially after the debridement of spinal tuberculosis, how to solve the large bone defect after debridement, the recurrence of local tuberculosis abscess, and how to shorten the course of treatment or administration of anti-tuberculosis drugs are not effective. The problem of treatment means, the present invention provides a kind of novel bone repair material with PLGA (polylactic acid-polyglycolic acid copolymer), calcium sulfate hemihydrate as carrier

Method used

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  • Bone-repairing material and preparing method thereof

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Experimental program
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Effect test

Embodiment 1

[0039] 1 Materials and methods

[0040] 1.1 Materials

[0041] PLGA (85 / 15) was provided by Chengdu Organic Chemistry Co., Ltd., Chinese Academy of Sciences, with a relative molecular mass of 300,000; calcium sulfate hemihydrate crystals were provided by Wright Company; rifampicin reference substance was provided by Qingdao Sangon Biotechnology Co., Ltd.

[0042] 1.2 Method

[0043] 1.2.1 Preparation of materials

[0044] Calcium sulfate hemihydrate: PLGA: sodium chloride: rifampicin=1:1:2:0.08 (mass ratio), wherein calcium sulfate hemihydrate and PLGA are slow-release carriers, sodium chloride is a porogen, and sodium chloride The crystal particle size is 180-250 μm. The materials were sterilized with ethylene oxide separately, and the following processing was carried out in a sterile environment.

[0045] (1) Organic solvent injection molding: according to the formula, a certain amount of PLGA is added into chloroform, fully magnetically stirred, and a solution with a co...

Embodiment 2

[0058] The proportion of raw materials used in the manufacture of bone repair materials in this embodiment is as follows:

[0059] PLGA: calcium sulfate hemihydrate: sodium chloride granules: rifampicin = 40:20:80:2.

[0060] The calcium sulfate hemihydrate refers to powder with a particle size below 80um; the PLGA refers to PLGA with a molecular weight of 3-100,000; the sodium chloride refers to sodium chloride crystal particles of 200-600um.

[0061] The method for manufacturing the bone repair material in this embodiment is as follows:

[0062] 1) Add the amount of PLGA into chloroform to form a 15-25% solution, seal and let stand for 10-14 hours;

[0063] 2) Add the amount of rifampicin, calcium sulfate hemihydrate, and sodium chloride into the solution and fully stir and weigh the mixture;

[0064] 3) volatilize the solvent from the mixture obtained in step 2) at room temperature, and solidify;

[0065] 4) Soak the cured product obtained in step 3) in double-distilled ...

Embodiment 3

[0077] The proportion of raw materials used in the manufacture of bone repair materials in this embodiment is as follows:

[0078] PLGA: calcium sulfate hemihydrate: sodium chloride granules: rifampicin = 40:80:20:8.

[0079] The calcium sulfate hemihydrate refers to powder with a particle size below 80um; the PLGA refers to PLGA with a molecular weight of 3-100,000; the sodium chloride refers to sodium chloride crystal particles of 200-600um.

[0080] The method for manufacturing the bone repair material in this embodiment is as follows:

[0081] 1) Add the amount of PLGA into chloroform to form a 20% solution, seal and let stand for 12 hours;

[0082] 2) Add the amount of rifampicin, calcium sulfate hemihydrate, and sodium chloride particles into the solution and stir thoroughly. Until it is evenly distributed in the solution, the solution is gelatinous at this time;

[0083] 3) The mixture obtained in step 2) was placed in a room-temperature fume hood to volatilize for 2...

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Abstract

The invention relates to a bone rehabilitating material and a preparation method of the material. The invention provides a bone rehabilitating material, the effective components of which are prepared by the following weights and portions of raw materials: 40 of a PLGA; 20 to 80 of a semi-hydrated calcium sulphate; 2 to 8 of a rifampicin. The invention also provides the preparation method of the bone rehabilitating material. The invention mixes and solidifies the semi-hydrated calcium sulphate, the PLGA, the rifampicin and a sodium chloride granule and digests the sodium chloride granule to make a novel multi-hole bone rehabilitating material with a function of anti-bacillus tuberculosis.

Description

technical field [0001] The invention relates to a bone repair material and a preparation method thereof. Background technique [0002] The materials currently used for bone disease treatment can be roughly divided into two categories: [0003] Non-biodegradable type: including polyethylene, polypropylene, polyacrylate, aromatic polyester, polysiloxane, polyoxymethylene, etc., which can remain stable for a long time in a biological environment without degradation, cross-linking or physical wear, etc., and Has good physical and mechanical properties. [0004] Biodegradable type: including polylactic acid, polycaprolactone, polyvinyl alcohol, linear aliphatic polyester, etc., which can undergo structural damage and performance degradation in a biological environment, and their degradation products can be absorbed and utilized by the body through normal metabolism Or excreted from the body, they are mainly used for drug release, delivery carrier, bone repair material, cell sca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/50
Inventor 徐华梓应小樟彭磊
Owner WENZHOU MEDICAL UNIV
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