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Compound chemical medicine with antitussive and phlegm-eliminating action and its preparation technology

A technology for eliminating phlegm and making compound prescriptions, which is applied in the field of compound chemical medicines

Active Publication Date: 2011-03-16
太阳升(亳州)生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical trials have shown that ideal antitussives should reduce the sensitivity of sensory nerves in the lungs and block sensory nerve conduction in myelinated or unmyelinated nerves (such as local anesthetics), but local anesthetics can inhibit lung defenses Side effects such as reflexes and induction of bronchoconstriction

Method used

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  • Compound chemical medicine with antitussive and phlegm-eliminating action and its preparation technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take levodropropizine 60g, guaiacol glyceryl ether 100g, be prepared into tablet as follows:

[0018] Weigh an appropriate amount of auxiliary materials lactose, hydroxypropylmethylcellulose (15cp), magnesium stearate, and another appropriate amount of titanium dioxide, polyethylene glycol 400, hydroxypropylmethylcellulose (7cp) for coating. For auxiliary materials, the raw and auxiliary materials are respectively pulverized, passed through a 100-mesh sieve, and set aside. Firstly mix all excipients (except magnesium stearate), then add levodropropizine and guaiacol glycerin and mix well. Then use 70% ethanol to make soft material, granulate with 24-mesh sieve, bake at 60-65°C for 2 hours until the moisture is about 1-3%, granulate with 24-mesh sieve, add magnesium stearate, and mix well. Compressed, ready for coating. Dissolve the weighed hydroxypropylmethylcellulose in 70% ethanol and let it stand overnight. Weigh and measure the titanium dioxide and polyethylene g...

Embodiment 2

[0033] Take levodropropizine 50g, guaiacol glyceryl ether 150g, prepare oral liquid according to the following method:

[0034] Weigh or measure an appropriate amount of auxiliary materials such as ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, aspartame, methyl cellulose, lemon, etc., crush and sieve the raw and auxiliary materials respectively for later use. Add ethanol to the prepared raw and auxiliary materials, stir and dissolve, and add water to 1000ml to obtain.

Embodiment 3

[0036] Weigh an appropriate amount of levodropropizine and guaiacol glyceryl ether, and prepare capsules according to the following method:

[0037] Weigh an appropriate amount of povidone, lactose, microcrystalline cellulose, talcum powder, starch and magnesium stearate. Use dilute ethanol as a wetting agent for the starch, and form a pill, and take a ball core with a size of 20 to 35 mesh for later use. Spray the surface of the core with 3% povidone ethanol, add the mixed levodropropizine, microcrystalline cellulose and talcum powder to make it adhere to the surface of the core, and blow it with hot air until the surface is dry , placed in an oven to dry. Guaifenesin-containing pills are made in the same way. Both of them use pills with a size of 20-35 meshes and measure the content for later use. Then weigh appropriate amount of cellulose acetate, polyacrylic acid resin, sodium lauryl sulfate, and talcum powder and dissolve them in 90% ethanol to prepare a coating soluti...

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Abstract

The invention provides a compound chemical medicament with cough relieving and expectorant effects and its preparation method, especially relates to a medicament composed of levodropropizine and guaiphenesin as active ingredient and pharmically receivable adjuvant and its production technology. Levodropropizine adopted in the invention is peripheral antitussive. Compared with present conventionalcentral antitussive, it has good antitussive effect and less adverse reaction.

Description

field of invention [0001] The invention belongs to the field of chemical drugs, and relates to a compound chemical drug for antitussive and expectorant and a preparation process thereof, in particular to a compound chemical drug with levodropropizine and guaiacol glyceryl ether as active ingredients. Background technique [0002] Cough and expectoration are common clinical symptoms of respiratory diseases. Mild but infrequent cough can be relieved naturally without medication as long as the sputum or foreign matter can be discharged. However, excessive coughing not only increases the pain of the patient, affects rest and sleep, increases physical exertion, and even promotes the development of the disease, resulting in other complications, such as pneumonia, chronic pharyngitis, chronic bronchitis, bronchiectasis, lung abscess and cavity type pulmonary tuberculosis etc. At this time, in addition to prescribing the right medicine for respiratory diseases, it is also necessar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/495A61K31/085A61K9/20A61K9/48A61K9/08A61P11/10A61P11/14
Inventor 朱志宏卜振军杨静
Owner 太阳升(亳州)生物医药科技有限公司
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