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Multifunctional membrane used for glaucoma post-operation and preparation method thereof

A post-operative, multi-functional technology, applied in the field of medicine, can solve the problems of limited wide application, side effects, etc., and achieve the effect of obvious curative effect, long residence time, and prevention of adhesion

Inactive Publication Date: 2007-11-28
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of chitosan in the human body has certain side effects, which limits its wide application in medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Dissolve a certain amount of chitosan in 1wt% acetic acid solution, filter, let it stand for defoaming, then naturally salivate into a film on a clean glass plate, dry, and then put the film in 1M sodium hydroxide solution for 12h After that, take it out and soak it in distilled water for 8 hours, then rinse it repeatedly with distilled water, and dry it to obtain a chitosan film. Then put the film into the mixture of methanol and acetic anhydride, take it out after 12 hours, soak it in distilled water for 8 hours, rinse it repeatedly with distilled water, and dry it to get the acetylated chitosan film. Take a transparent modified chitosan film of a certain size, immerse it in physiological saline containing a certain amount of mitomycin, soak for a certain period of time, take it out, and dry it to obtain a lavender acetylated chitosan mitomycin film.

Embodiment 2

[0016] The chitosan film was prepared as in Example 1. Then put the membrane into the mixed solution of methanol and hexanoic anhydride, take it out after 12 hours, soak it in distilled water for 8 hours, rinse it repeatedly with distilled water, and dry it to get hexanoylated chitosan membrane. Take a transparent modified chitosan film of a certain size, immerse it in physiological saline containing a certain amount of mitomycin, soak for a certain period of time, take it out, and dry it to obtain a lavender caproylated chitosan mitomycin film.

Embodiment 3

[0018] The chitosan film was prepared as in Example 1. Then put the film into the mixed solution of methanol and benzoic anhydride, take it out after 12 hours, soak it in distilled water for 8 hours, rinse it repeatedly with distilled water, and dry it to get the benzoylated chitosan film. Take a transparent modified chitosan film of a certain size, immerse it in physiological saline containing a certain amount of mitomycin, take it out after soaking for a certain period of time, and dry it to obtain a lavender benzoylated chitosan mitomycin film.

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Abstract

The present invention relates to medicine technology, and is especially one kind of eye implant with slowly released active component and post-operational adhesion preventing function. The eye implant consists of chitosan derivative and medicinal active component mainly, and is prepared into film implanted into eye tissue to slowly released active component and to avoid adhesion before degradation, needing no taking out. It is used mainly after glaucoma treating operation and has high medicine bioavailability.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to an ophthalmic implant capable of sustaining release of active ingredients and preventing postoperative adhesion and a preparation method thereof. Background technique [0002] Glaucoma is an irreversible blinding eye disease that seriously threatens visual function. According to epidemiological surveys, there are about 10 million glaucoma patients among the 1.3 billion population in my country, and there are more than 50,000 new patients every year. There are three types of treatment for glaucoma: drug therapy, laser therapy and surgical treatment, among which surgical treatment is the main means for glaucoma that has poor efficacy or cannot be controlled after drug and laser treatment. The purpose of surgical treatment is to establish a new drainage channel outside the eye, reduce intraocular pressure, relieve the damage of retinal ganglion cells and fibers caused...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/407A61K9/70A61K47/36A61P41/00A61P27/00A61L15/44A61L15/28
Inventor 王爱勤韦萍汪琴
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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