Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

'Yanhuning' frozen-dried powder injection and its preparation method

A technology of freeze-dried powder injection and Yanhuning, which is applied in the field of Yanhuning freeze-dried powder injection and its preparation, can solve the problem of content decline, unstable pH environment, fast, and some content will drop to the lower limit after one year, etc. problem, to achieve the effect of slow oxidation, stable pH environment, and improved shelf life

Active Publication Date: 2007-10-24
HARBIN ZHENBAO PHARMA
View PDF0 Cites 19 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Store it according to the storage conditions (airtight, in a cool and dry place), because the pH environment is unstable, so the content drops quickly, and some content drops to the lower limit after one year, and cannot reach the 2-year validity period

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • 'Yanhuning' frozen-dried powder injection and its preparation method
  • 'Yanhuning' frozen-dried powder injection and its preparation method
  • 'Yanhuning' frozen-dried powder injection and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation of Yanhuning freeze-dried powder injection

[0020] Take 800g of Yanhuning, dissolve it with 14000ml of 55℃ water for injection and keep it at 50℃~55℃, and adjust the pH value to 6.7; take 89.6g of disodium hydrogen phosphate and 64.5g of sodium dihydrogen phosphate respectively, and dissolve them in 1000ml of water for injection ; Take 6g of L-cysteine ​​hydrochloride, dissolve it with 1000ml of water for injection, mix the above three solutions evenly, adsorb on activated carbon, remove carbon, adjust the pH value to 6.8, add water for injection to 20000ml, stir well, 30 Fine filtration below ℃, filling, semi-corking, freeze-drying, corking, capping, visual inspection, packaging, and the finished product is obtained.

Embodiment 2

[0021] Example 2 Preparation of Yanhuning freeze-dried powder injection

[0022] Take 720g of Yanhuning, dissolve it with 12000ml of water for injection at 50°C, and adjust the pH to 6.0; take 80.64g of disodium hydrogen phosphate and 50.05g of sodium dihydrogen phosphate, and dissolve it with water for injection; take L-cysteine ​​salt Salt 4.9g, dissolve with water for injection, mix the above three solutions evenly, add activated carbon for adsorption at 0.4% by weight, remove carbon, adjust the pH value to 6.3, add water for injection to 13000ml, stir evenly, and refine at 30°C Filtration, filling, semi-stoppering, freeze-drying, stoppering, capping, visual inspection, packaging, and the finished product is obtained.

Embodiment 3

[0023] Example 3 Preparation of Yanhuning freeze-dried powder injection

[0024] Take 880g of Yanhuning, dissolve it with 13000ml of water for injection at 60°C, and adjust the pH value to 7.0; take 98.56g of disodium hydrogen phosphate and 70.95g of sodium dihydrogen phosphate, and dissolve it with 1000ml of water for injection; take L-cysteine Hydrochloride 7.6g, dissolved with 1000ml of water for injection, mixed the above three solutions evenly, added activated carbon to absorb for 20 minutes according to the weight ratio of 0.7%, removed carbon, adjusted the pH value to 6.9, added water for injection to 25000ml, stirred evenly, Fine filtration below 30°C, filling, semi-corking, freeze-drying, corking, capping, visual inspection, packaging, and the finished product is obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a freeze dried injection of potassium sodium dehydroandrographolide succinate which is prepared from potassium sodium dehydroandrographolide succinate, ionic cushion pairs and anti-oxidizing agents, the preferred ionic cushion pairs being phosphate cushion pairs, and the antioxidant can be L-cysteine hydrochloride.

Description

technical field [0001] The invention relates to a medicament and a preparation method thereof, in particular to Yanhuning freeze-dried powder injection and a preparation method thereof. Background technique [0002] Yanhuning, chemical name: 14-dehydroxy-11,12-didehydroandrographolide-3,19-disuccinate half ester potassium sodium salt, molecular formula: C28H34KNaO10·H2O; molecular weight: 610.68. It can inhibit early capillary permeability increase and inflammatory exudation and edema, can specifically stimulate the pituitary-adrenal cortex function, promote the release of ACTH, and increase the biosynthesis of ACTH in the anterior pituitary; in vitro it has inactivated adenovirus, The role of various viruses such as influenza virus and respiratory virus. Animal experiments have anti-early and middle-pregnancy effects. It has heat-clearing, detoxifying and antiviral effects, and is mainly used for viral pneumonia and viral upper respiratory tract infections. [0003] The ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/365A61K9/19A61K47/16A61P11/00A61P31/12
Inventor 方同华
Owner HARBIN ZHENBAO PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com