Four-in-one bioartificial liver online monitoring and constant temperature heating integrated system

Abstract

The invention discloses a four-in-one bioartificial liver on-line monitoring and constant temperature heating integrated system, comprising sequentially connected blood input ports, blood pumps, arterial pots, four-in-one bioreactors, venous pots and blood return ports; four-in-one The bioreactor includes a constant temperature water tank and a three-in-one bioreactor placed inside it; the three-in-one bioreactor includes a cavity and a first partition and a second partition arranged in the cavity; the first partition and the second partition The two partitions divide the cavity into three independent spaces from left to right, which are plasma separator, oxygenator and reactor in turn; the constant temperature water tank includes the water tank shell and the hot water inlet and hot water outlet on the water tank shell . The beneficial effects of the present invention are: after the blood enters the plasma separator, the plasma enters the oxygenator and the reactor in turn, reducing unnecessary pipelines; it can provide a suitable metabolic environment for cells and ensure cell activity; it can increase the effective cell filling volume and ensure The cells are evenly distributed laterally.

Description

technical field [0001] The invention belongs to the technical field of bioartificial liver, and in particular relates to a four-in-one bioartificial liver online monitoring and constant temperature heating integrated system. Background technique [0002] my country is the country with the most serious liver disease in the world. The number of new cases of liver failure exceeds 1 million every year, and about 50% of patients with liver failure die due to lack of effective treatment. At present, liver transplantation is the most effective treatment for liver failure. However, due to the difficulty in obtaining livers, long waiting times, or no chance to obtain a donor liver, the vast majority of patients have no chance of survival. Therefore, an artificial liver system is urgently needed to maintain the patient's life, waiting for the opportunity of liver transplantation, or the opportunity of the patient's own liver recovery. [0003] The bioartificial liver support system m...

AI Technical Summary

Problems solved by technology

Plasma separator, oxygenator and bioreactor have high cost and cumbersome operation, which needs to be further optimized

Moreover, the existing bioartificial liver reactor only uses a warmer to increase the temperature, and cannot heat the bioartificial liver reactor at a constant temperature. The heating is unstable and affects the efficiency of the bioartificial liver reactor.

Moreover, the currently commonly used bioartificial liver reactor is a hollow fiber reactor. In this reactor, the fiber tubes are closely arranged, the volume between the fiber tubes is small, and the central part is not easy to load cells, which may easily cause uneven cell distribution and lead to systemic detoxification. The performance is reduced, and the cells are easy to block the micropores of the membrane wall of the fiber tube when the cells grow on the wall of the fiber tube, affecting the material exchange inside and outside the fiber tube, which is not conducive to the long-term effective maintenance of the function and vitality of the liver cells and seriously affects the therapeutic effect

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