Cinnarizine drop pills, and preparation method
A technology of cinnarizine and dropping pills, which is applied in the field of cinnarizine dropping pills and its preparation, can solve the problems of difficulty in adapting to swallowing, affecting the full effect of the drug, and low bioavailability, so as to be beneficial to human body absorption, Increased bioavailability, high bioavailability effect
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Embodiment 1
[0026] Example 1: In this example, the formulation of cinnarizine and a single matrix is used to operate according to the preparation method in [Specific Embodiment], the coolant is simethicone oil, dripping pills are made, and the roundness, pill weight difference, Hardness, dissolving time, etc. are used as indicators to observe the influence of the weight ratio of the drug to the single matrix on the product involved in the present invention. The test results are shown in Table 1.
[0027] Table 1 Tests of drug and single matrix formulation (all drugs are 1 part)
[0028]
[0029] 5
Polyethylene glycol 6000 (3 parts)
+++
<10
+++
<15
+++
6
Polyethylene glycol 6000 (9 parts)
+++
<10
+++
<15
+++
7
Polyethylene glycol 10000 (1 part)
too thick to drip
8
Polyethylene glycol 10000 (3 parts)
+++
<10
+++
<15
++...
Embodiment 2
[0032] Example 2: In this example, the formula of cinnarizine and mixed matrix is used, and the preparation method in [specific implementation] is operated. The coolant is simethicone oil, and dripping pills are made, and the roundness, pill weight difference, Hardness, dissolving time etc. are investigation indexes, observe the influence of the weight ratio of medicine and mixed matrix on the product involved in the present invention, test result is shown in Table 2.
[0033] Table 2 Drug and mixed matrix formulation test (1 part of drug)
[0034]
[0035] 7
Polyethylene glycol 6000: poloxamer = 1:
0.2 (1 part)
+++
<10
++
<15
++
8
Polyethylene glycol 6000: poloxamer = 1:
0.2 (3 parts)
+++
<10
+++
<15
+++
9
Polyethylene glycol 6000: poloxamer = 1:
0.2 (9 parts)
+++
<10
+++
...
Embodiment 3
[0038] Embodiment 3: In this embodiment, different coolants are selected, and the coolant is simethicone, liquid paraffin, vegetable oil, and polyethylene glycol is selected as a single matrix 6000 , the mixed matrix chooses polyethylene glycol 6000 : the formula of poloxamer=1:0.2, operate according to the preparation method in [the specific embodiment], drip dripping pill, select roundness, pill weight difference, hardness, dissolving time etc. as investigation index, observe different The impact of coolant on the products involved in the present invention, the test results are shown in Table 3.
[0039] Table 3 Experiments using different coolants (drug: matrix = 1:3)
[0040]
[0041] 5
single
++
<10
+++
<15
++
6
mix
++
<10
+++
<15
++
[0042] Note: 1. The cooling temperature is 8-5°C; the heat preservation temperature of the d...
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