Bisoprolol Fumarate drop pills, and preparation method
A technology of bisoprolol fumarate and fumaric acid, applied in the field of bisoprolol fumarate drop pills and its preparation, can solve problems such as difficulty in adapting to swallowing, affecting full efficacy of the drug, and low bioavailability , to achieve the effect of being beneficial to labor protection and environmental protection, beneficial to human body absorption, and high bioavailability
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Embodiment 1
[0026] Example 1: In this example, the formulation of bisoprolol fumarate and a single matrix is used to operate according to the preparation method in the [specific implementation method]. The coolant is simethicone oil, and dripping pills are made, and the roundness and pills are selected. Weight difference, hardness, dissolution time, etc. are used as indicators to observe the influence of the weight ratio of the drug to the single matrix on the product involved in the present invention. The test results are shown in Table 1.
[0027] Table 1 Tests of drug and single matrix formulation (all drugs are 1 part)
[0028]
[0029] 2
Polyethylene glycol 4000 (5 parts)
+++
<10
+++
<15
+++
3
Polyethylene glycol 4000 (15 parts)
+++
<10
+++
<15
+++
4
Polyethylene glycol 4000 (30 parts)
+++
<10
+++
<15
+++
5
Polyethylene glyco...
Embodiment 2
[0032] Example 2: In this example, through the formula of bisoprolol fumarate and mixed matrix, operate according to the preparation method in the [specific implementation method], the coolant is simethicone oil, and drop pills are made, and the roundness and pills are selected. Weight difference, hardness, dissolution time, etc. were used as investigation indicators to determine the weight ratio of the drug to the mixed matrix. The test results are shown in Table 2.
[0033] Table 2 Drug and mixed matrix formulation test (1 part of drug)
[0034]
[0035] 6
Polyethylene glycol 6000: carboxymethyl starch
Sodium = 1:0.3 (15 parts)
+++
<10
+++
<15
+++
7
Polyethylene glycol 6000: poloxamer = 1:
0.2 (1 part)
+++
<10
++
<15
++
8
Polyethylene glycol 6000: poloxamer = 1:
0.2 (5 parts)
+++
<10
...
Embodiment 3
[0038] Embodiment 3: In this embodiment, different coolants are selected, and the coolant is simethicone, liquid paraffin, vegetable oil, and polyethylene glycol is selected as a single matrix 6000 , the mixed matrix chooses polyethylene glycol 6000 : the formula of poloxamer=1:0.2, operate according to the preparation method in [the specific embodiment], drip dripping pill, select roundness, pill weight difference, hardness, dissolving time etc. as investigation index, observe different The impact of coolant on the products involved in the present invention, the test results are shown in Table 3.
[0039] Table 3 Experiments using different coolants (drug: matrix = 1:5)
[0040]
[0041] 3
single
++
<10
+++
<15
++
4
mix
++
<10
+++
<15
++
5
single
++
<10
+++
<15
++
...
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