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Medicine compound made of haw leaf and rhodiola

A composition, the technology of hawthorn leaves, applied in the field of medicine, achieves remarkable curative effect, improves myocardial blood supply, and inhibits platelet aggregation

Inactive Publication Date: 2007-09-26
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Utilizing the interaction of hawthorn leaves and Rhodiola rosea, the compatible prescription is used to prepare drugs for treating cardiovascular and cerebrovascular diseases, which has not been reported yet

Method used

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  • Medicine compound made of haw leaf and rhodiola

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Example 1 Preparation of total flavonoids from hawthorn leaves

[0101] Take hawthorn leaves, add 75% ethanol to reflux and extract three times, each time for 1.5 hours, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell, add an equal amount of water to dilute, and degrease with 1 / 2 amount of petroleum ether Finally, the petroleum ether liquid was discarded, and then extracted with ethyl acetate. The extract was decompressed to recover the ethyl acetate and concentrated to dryness to obtain the total flavonoids of hawthorn leaves (for oral preparations). Take the above total flavonoids of hawthorn leaves, add an appropriate amount of water to dissolve, add to the treated polyamide column, first elute with 2 times the column volume of water, discard the washing solution, and then use 3 times the column volume of 70% ethanol Elute, collect the eluate, recover ethanol and concentrate to a concentrate...

Embodiment 2

[0116] Example 2 Preparation of Rhodiola Rosea Extract

[0117] Take Rhodiola rosea medicinal material, crush it into coarse powder, extract three times with 70% ethanol for 1 hour each time, add alcohol 10 times the amount for the first time, and add 8 times and 8 times the amount for the second and third times respectively. Filtrate, combine the extracts, recover ethanol until every 5ml contains 1g raw medicinal materials, degrease with 2 times the amount of petroleum ether, discard the petroleum ether liquid, then extract with n-butanol saturated with water, concentrate under reduced pressure to a thick paste, spray After drying, the crude extract of Rhodiola rosea is obtained.

[0118] Dissolve the crude extract of Rhodiola rosea with appropriate amount of water, put it on the pre-treated macroporous resin column, and elute with water, 10% ethanol, 15% ethanol, 20% ethanol, and 30% ethanol in sequence. Ethanol is recovered under reduced pressure to a relative density of 1...

Embodiment 3

[0129] Example 3 Preparation of SH Composition Aqueous Injection

[0130] prescription:

[0131] Hawthorn leaves total flavonoids 50.2g (equivalent to 2kg hawthorn leaves)

[0132] Rhodiola rosea extract 25.0g (equivalent to Rhodiola rosea 1kg)

[0133] Add water for injection to 5000ml

[0134] A total of 1000 sticks were prepared

[0135] Preparation Process:

[0136] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0137] 2) Take 80% of the water for injection, add the prescribed amount of total flavonoids of hawthorn leaves and rhodiola rosea extract, heat and stir to dissolve completely.

[0138] 3) Add water for injection to the full amount.

[0139] 4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.

[0140] 5) Decarburization by sand filter stick filtration. Measure and adjust the pH of the solution.

[0141] 6) Fine fi...

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Abstract

The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and its preparing process, wherein the composition is prepared mainly from the haw thorn leaves and rhodiola root by a weight ratio of 1:0.05-10, or is prepared from haw thorn leaves flavones and rhodiola root extract by a weight ratio of 1:0.05-10. The pharmaceutical composition can be prepared into any clinically or pharmaceutically acceptable dose forms.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition of hawthorn leaf or its extract and rhodiola rosea or its extract for treating cardiovascular and cerebrovascular diseases, a preparation containing the pharmaceutical composition and a preparation method thereof. [Background technique] [0002] Cardiovascular and cerebrovascular disease is a common disease that seriously threatens the health of middle-aged and elderly people, and is known as the "first killer" of human health. According to my country's epidemiological survey, the percentage of deaths from cardiovascular and cerebrovascular diseases in the total death population in my country has risen from 12.07% in 1957 to 42.6% in 2001, and 2 million people die from cardiovascular and cerebrovascular diseases every year. Therefore, to reveal the mechanism of the occurrence and development of cardiovascular and cerebrovascular diseases, to carry ou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61P9/10A61P7/02A61P3/06
Inventor 黄振华
Owner JIANGYIN TIANJIANG PHARMA
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