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Powderd injecta of compounded glycyrrhizin and preparing method

A technology of compound licorice and glycyrrhizin, applied in the field of medicine, can solve the problems of inconvenient transportation, difficult hemolysis, unsuitable for long-term storage, etc., and achieve the effect of reducing the probability of pollution, clear solution, and full form

Inactive Publication Date: 2007-08-29
XINMA MEDICINE SCI TECH SHENYANG
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are sales of water injection preparations in the market, but because water injection preparations are not suitable for long-term storage, inconvenient transportation, and because of the intermediate link of sealing needle extraction and injecting large infusion, it is easy to cross-contaminate, so our company adopts advanced freeze-drying technology , developed into a freeze-dried powder preparation for compound glycyrrhizin injection. Compared with the original dosage form, the powder preparation for compound glycyrrhizin injection can improve the stability of the drug, avoid intermediate links, reduce pollution, and facilitate transportation. The powder preparation for sweetin injection solves the problem of the clarity of the sample, so that the sample solution does not have crystallization at room temperature, and the clarity meets the requirements; the added calcium sodium edetate is less hemolytic than sodium edetate, and is suitable for injection. make prescriptions more reasonable

Method used

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Embodiment Construction

[0074] prescription:

[0075] Glycyrrhizin 40g

[0076] (Monoammonium Glycyrrhizinate S 50g)

[0077] L-cysteine ​​hydrochloride 20g

[0078] Glycine 400g

[0079] Sodium sulfite 16g

[0080] Sodium Calcium Edetate 1g

[0081] Appropriate amount of sodium hydroxide

[0082] Add water for injection to 3000ml

[0083] 1000 pieces

[0084] Preparation Process

[0085] 1. Weigh monoammonium glycyrrhizinate S, L-cysteine ​​hydrochloride, and glycine into a sterilized container, add 1800-2400ml of water for injection, stir to dissolve in a water bath at 37°C, then add sodium sulfite, Sodium Calcium Edetate. Stir to dissolve, add water to 2500ml, adjust the pH value to 6.0-7.0 with 1.0mol / L sodium hydroxide solution, add 0.1% (w / w) activated carbon in the prescribed amount, keep stirring at 80°C for 40 minutes, and use sterile Filtrate and decarburize with a suction filtration device, add water for injection to 5000ml, test pH = 6.0~7.0, then pass ...

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Abstract

The present invention relates to a compound glycyrrhizin powder injection preparation and its preparation method. It is made up by using monoammonium salt glycyrrhizinate, cysteine L-hydrochloride, glycine, anhydrous sodium sulfite, calcium sodium egtazate sodium hydroxide solution and sterile injection water through a certain preparation process.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to a compound glycyrrhizin injection powder preparation and a preparation method thereof. Background technique: [0002] Hepatitis is an infectious disease with a high incidence worldwide, especially in East Asia and Southeast Asia. There are about 300 million people in the world suffering from liver diseases. my country is a high-incidence area of ​​liver disease, with about 2 million cases of acute hepatitis and about 30 million patients with chronic hepatitis B every year. Chronic hepatitis is very harmful, but the clinical treatment is not standardized enough. Compound glycyrrhizin has direct anti-hepatitis B virus effect, improvement effect on liver dysfunction and immune regulation effect. Animal experiments have shown that it has the effect of promoting liver cell regeneration, can drive fat and inhibit the proliferation of liver fibrous tissue, and significantly reduce the inflamm...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K9/14A61K9/19A61P1/16A61K31/197
Inventor 李献阳
Owner XINMA MEDICINE SCI TECH SHENYANG
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