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Coenzyme Q10 oral emulsion and preparing process thereof

An auxiliary emulsifier and coenzyme technology, applied in the field of medicine, can solve the problems of low bioavailability, easy precipitation of drugs, poor stability of coenzyme Q10 injection, etc., and achieve the effects of high bioavailability, good stability and easy taking

Inactive Publication Date: 2007-08-15
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Coenzyme Q10 products on the market mainly include tablets, capsules, injections, etc. Tablets and capsules are not suitable for patients with dysphagia and have low bioavailability; easy to separate out

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Medicinal soybean oil (a) 15% (mL / 100mL)

[0026] Coenzyme Q10(b) 0.5% (g / 100mL)

[0027] Tween 80(c) 6% (mL / 100mL)

[0028] Span 80(d) 1.5% (mL / 100mL)

[0029] Vitamin E (e) 0.1% (g / 100mL)

[0030] Povidone K90(f) 1% (g / 100mL)

[0031] (a), (b), (c), (d), (e) and other oil-soluble components are mixed evenly to prepare a medicinal solution for use; the purified water and (f) are mixed and dissolved, then added to the oil phase, and ultrasonically Emulsifier dispersion, 600w, three minutes, repeat twice, filter, potting, sterilization, numbering, the product is obtained.

Embodiment 2

[0033] Medicinal soybean oil (a) 20% (mL / 100mL)

[0034] Coenzyme Q10(b) 1% (g / 100mL)

[0035] Tween 80(c) 8% (mL / 100mL)

[0036] Span 80(d) 2% (mL / 100mL)

[0037] Vitamin E (e) 0.1% (g / 100mL)

[0038] Povidone K90(f) 1% (g / 1 00mL)

[0039] (a), (b), (c), (d), (e) and other oil-soluble components are mixed evenly to prepare a medicinal solution for later use; add purified water according to the ratio of oil: water: emulsifier of 4:2:1 (containing 1% povidone K90), stirred with a high-speed stirrer at 18000r / min for 5 minutes to obtain colostrum, and then gradually diluted to the full amount with the remaining purified water (containing 1% povidone K90). Filtration, potting, sterilization, numbering, the product is obtained.

Embodiment 3

[0041] Medicinal soybean oil (a) 15% (mL / 100mL)

[0042] Coenzyme Q10(b) 0.5% (g / 100mL)

[0043] Tween 80(c) 6% (mL / 100mL)

[0044] Span 80(d) 1.5% (mL / 100mL)

[0045] Vitamin E (e) 0.1% (g / 100mL)

[0046] Povidone K90(f) 1% (g / 100mL)

[0047] (a), (b), (c), (d), (e) and other oil-soluble components are mixed evenly, and preheated at 50°C to prepare a medicinal solution for later use; under slow stirring, 50 °C preheated purified water (containing 1% povidone K90) is added to the preheated oil phase, and a stable o / w emulsion is formed as the water volume increases. Filtration, potting, sterilization, numbering, the product is obtained.

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Abstract

The invention relates to a coenzyme Q10 oral emulsion and its preparation method, wherein the constituents include coenzyme Q10 0.1-80%, medicinal oil 1-95%, emulsifying agent 0.5-30%, auxiliary emulsifying agent 0-10%, anti-oxidant 0.001-15%, and balancing purified water. The emulsion can be prepared through inversion phase emulsification method, PIT emulsification method, alternative liquid feeding emulsification method, or continuous emulsification method.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an oral emulsion of coenzyme Q10 and a preparation method thereof. Background technique [0002] Coenzyme Q10 is a breakthrough nutrient that helps fight heart disease, cancer, aging and more. Its basic function is to promote the energy metabolism of the body. The role is to protect the heart, lower blood pressure, enhance immunity, etc. It is now more believed that its effect is similar to that of vitamin E, and it is also an antioxidant, so it is beneficial to prevent diseases related to free radical pathology. [0003] Exogenous coenzyme Q10 has a variety of pharmacological effects such as anti-oxidation, free radical scavenging, biofilm stabilization, anti-shock, immune function enhancement and respiratory system. [0004] Coenzyme Q10 is widely used, and it is mainly used clinically as an adjuvant drug for cardiovascular diseases, acute and chronic hepatitis, and cancer. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/122A61P39/06
Inventor 邓英杰高晓菲李喆
Owner SHENYANG PHARMA UNIVERSITY
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