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Electromagnetic impulse irradiation system and method for promoting medicament to permeate bloodbrain barrier

An electromagnetic pulse and blood-brain barrier technology, applied in the medical field, can solve problems such as large side effects, and achieve the effects of avoiding side effects, simple and easy regulation, and convenient adjustability

Active Publication Date: 2007-08-08
郭国祯 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large clinical side effects caused by microwave heating, which limited its application, the study could not be continued

Method used

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  • Electromagnetic impulse irradiation system and method for promoting medicament to permeate bloodbrain barrier
  • Electromagnetic impulse irradiation system and method for promoting medicament to permeate bloodbrain barrier
  • Electromagnetic impulse irradiation system and method for promoting medicament to permeate bloodbrain barrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 Composition and mode of action of the electromagnetic pulse irradiation system based on SOS

[0016] The SOS-based electromagnetic pulse radiation system consists of a pulse generator, a controller 8, an irradiator 7, and a bed 14 where the irradiator is placed (see Figures 1 and 2).

[0017] The pulse generator is composed of a constant current charging power supply 1 , an energy storage capacitor 2 , a thyristor 3 , a magnetic pulse compressor 4 , a semiconductor circuit breaker 5 and an absorption load 6 . As shown in FIG. 2 , the irradiator 7 is composed of a pulse signal input terminal 9 , a radiation electrode 10 , a shielding case 11 , a rotating shaft 12 of the shielding case, and a radiator base 13 . The system also includes a patient bed 14 on which the irradiator 7 is placed. Under the action of the controller 8, the pulse generator generates high-voltage pulses with adjustable repetition frequency and amplitude.

[0018] In the above system, t...

Embodiment 2

[0021] Embodiment 2 The use method of the electromagnetic pulse irradiation system based on SOS

[0022] Referring to Fig. 2, the usage method of the electromagnetic pulse irradiation system will be described.

[0023] 1) Turn on the power supply 1;

[0024] 2) Set the repetition frequency, pulse amplitude, and number of pulses on the controller 8 according to the doctor's prescription. For example, the pulse width is 1ns-2μs, the pulse front is 0.2-100ns, and the repetition frequency is from single to tens of kilohertz;

[0025] 3) Open the shielding cover 11 along the rotating shaft 12;

[0026] 4) The patient lies flat on the hospital bed 14, and the head falls on the concave part of the irradiator base 13;

[0027] 5) Close the shielding cover 11 (before closing the shielding cover, the irradiator will not send pulses);

[0028] 6) Press the start switch located on the panel of the controller 8, the electromagnetic pulse irradiation system runs with the set repetition f...

Embodiment 3

[0030] Embodiment 3 Evan's blue (EB) tracing test

[0031] EB is a powdery dye that is almost 100% bound to albumin immediately after entering the blood. Albumin has a molecular weight of 67kDa and can hardly pass through the blood-brain barrier under normal circumstances. When the permeability of the blood-brain barrier is increased, EB-bound albumin can enter the brain tissue through the blood-brain barrier. When the excitation light wavelength is 550nm, red fluorescence can be seen under the fluorescence microscope.

[0032] Use the system of Implementation 1 to carry out the following tests:

[0033] 1. The electromagnetic pulse irradiation (EMP) field strength is 200kV / m, and different pulse times are used to observe the EB fluorescence changes in different parts of the rat brain. Figure 3 shows the results of this experiment. It can be seen that with the increase of the number of pulses (0-200 times), the area of ​​the above-mentioned spots increases, and the number ...

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Abstract

The invention relates to a mine disaster survival capsule, in which the workers can quickly enter in mine disaster, to be protected. And the survival capsule is sealed and vibration-insulated system, which can contain five people for more than five days. The invention is formed by a breath circulator, a living system, a discharge system, a lighting system, a sealed thermal-insulated vibration-insulated system, a communication system, and an emergency medical box; therefore, people can live in it freely.

Description

technical field [0001] The invention relates to the medical field, and further relates to a brain electromagnetic pulse irradiation system. Background technique [0002] Due to the existence of the blood-brain barrier, the application of many potential therapeutic drugs for diseases of the central nervous system is limited, which has become a bottleneck in the treatment of diseases of the central nervous system. When looking for new methods and new drugs to treat such diseases, people must consider how to effectively make drugs cross the blood-brain barrier and enter brain cells to achieve therapeutic purposes. There are currently three methods for drugs to cross the blood-brain barrier: hyperosmolar BBB opening, transporter-assisted entry method, and nanoparticle method. Due to various reasons such as expensive technical methods and side effects of extensive opening of the blood-brain barrier, the clinical application of these methods is limited. [0003] Using electromag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/02A61B18/18G21K5/00
Inventor 郭国祯刘国治
Owner 郭国祯
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