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Biodegradable imaging microspheres vascular embolization material containing drug

A biodegradable material and a biodegradable technology are applied in the field of drug-containing biodegradable imaging microsphere vascular embolization materials, which can solve the problems of invisibility and achieve the effects of not easy reflux, low product price and moderate specific gravity.

Inactive Publication Date: 2007-08-01
李艳芳 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these vascular embolic materials containing anti-tumor drugs disclosed in the prior art are invisible under X-rays

Method used

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  • Biodegradable imaging microspheres vascular embolization material containing drug

Examples

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Effect test

Embodiment 1

[0016] Embodiment 1: Drug-containing developing polylactic acid (PLA) microspheres of the present invention

[0017] Angiographic contrast agents purchased in the market, such as ionic contrast agent Urografin, are processed by vacuum freeze-drying, and the remaining substances after freeze-drying are retained as developing materials (2).

[0018] Choose only one of the following drugs as an antineoplastic drug (3), or choose a mixture of two or more of the following drugs as an antineoplastic drug (3), these drugs include: Carboplatin, cisplatin , Paclitaxel, Docetaxel, Oxaliplatin, Cyclophosphamide, Ifosfamide, Doxorubicin, Pegylated Liposomal doxorubicin), Epirubicin, Topotecan, Irinotecan, Etoposide (or VP-16), Bleomycin, Fluorouracil (Fluorouracil), Gemcitabine, Vincristine, Dactinomycin (Aeitinomycin), Paclitaxol (Taxol), or a blend of two or more of the above drugs, or other of the above drugs Derivatives and blends of derivatives, etc.

[0019] Polylactic acid is us...

Embodiment 2

[0024] Embodiment 2: Developing poly(lactic-co-glycolic acid) (PLGA) microspheres of the present invention

[0025] The production method of the product of this embodiment is basically the same as that of Example 1, except that the biodegradable material (1) is selected as a poly(lactic-co-glycolic acid) copolymer, and the developing material (2) can be selected from one of the following substances: ion Type contrast agent diatrizoate meglumine after vacuum freeze-drying; non-ionic contrast agent iohexol (Iohexol) or iopromide (Iopamidol) after vacuum freeze-drying The remaining substances after the treatment; the remaining substances after the non-ionic dimer iotrolan (Iotrolan) and other angiographic contrast agents have been processed by vacuum freeze-drying. Antineoplastic drugs (3) can be selected from one of the following substances: Carboplatin, Cisplatin, Paclitaxel, Docetaxel, Oxaliplatin, Cyclophosphamide (Cyclophosphamide), Ifosfamide, Doxorubicin, Pegylated liposoma...

Embodiment 3

[0027] Embodiment 3: Drug-containing developing polycaprolactone-polyglycolide-polyglycolide copolymer microspheres of the present invention

[0028] The production method of the product of this embodiment is basically the same as that of Example 1, except that the biodegradable material (1) is selected as polycaprolactone-polyglycolide-polyglycolide copolymer; the developing material (2) can be One of the following substances: the remaining substance after the ionic contrast agent diatrizoate meglumine has been processed by vacuum freeze-drying; the non-ionic contrast agent iohexol or iopromide or iodine Le (Iopamidol) residues after vacuum freeze-drying; non-ionic dimer iotrolan (iotrolan) and other angiographic contrast agents after vacuum freeze-drying residues; antineoplastic drugs (3) can be selected One of the following: Carboplatin, Cisplatin, Paclitaxel, Docetaxel, Oxaliplatin, Cyclophosphamide, Ifosfamide (Ifosfamide), Doxorubicin, Pegylated liposomal doxorubicin, E...

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Abstract

The invention discloses a biological decomposable developing micro sphere typed vascular plug material, which comprises the following parts: biological decomposable material, developing material without permeating X ray and antineoplastic agent, wherein the biological decomposable material parcels the particle structure of developing material and antineoplastic agent. The invention avoids excessive damage for organic, which can do MRI examination after plugging.

Description

technical field [0001] The invention relates to a blood vessel embolization material, in particular to a drug-containing biodegradable developing microsphere type blood vessel embolism material. Background technique [0002] In the prior art, there are many kinds of vascular embolization materials for intervention, mainly including polyvinyl alcohol (Polyvinyl Alcohol, PVA) microspheres, sodium alginate microspheres, gelatin sponge, surgical thread, stainless steel coils, platinum microcoils, Detachable balloons, cyanoacrylates, dehydrated ethanol, iodized oil, sodium morrhuate, etc. In clinical use, spring steel coils, surgical thread, and gelatin sponge have good clinical effects in embolizing large blood vessels, but the long-term efficacy is affected by the establishment of collateral circulation. Liquid embolic agents such as cyanoacrylates, dehydrated ethanol, iodized oil, and sodium morrhuate are prone to misembolization during clinical operations and are difficult t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/18A61L31/16A61L31/06
Inventor 李艳芳周泰立
Owner 李艳芳
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