Application of glycosamine for preparing medicine to relieve chronic pain

A technology for glucosamine and chronic pain, which is applied in the application field of glucosamine in the preparation of drugs for relieving chronic pain, and can solve the problem that non-steroidal anti-inflammatory drugs destroy internal environment stability, and cause drug tolerance, dependence and addiction. And other issues

Inactive Publication Date: 2007-07-18
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cyclooxygenase-1 is the main transmitter to maintain the internal environment of the kidney and liver, and the use of non-steroidal anti-inflammatory drugs will destroy the internal environment and cause various side effects
Opioid analgesics mainly act through endogenous opioid receptors in the central nervous system, but long-term use of opioids may cause side effects such as respiratory depression, sedation, nausea, vomiting, constipation, dizziness, and cognitive decline , and will produce drug tolerance, dependence and addiction, greatly limiting its clinical application

Method used

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  • Application of glycosamine for preparing medicine to relieve chronic pain
  • Application of glycosamine for preparing medicine to relieve chronic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1. Detection of the influence of glucosamine on the ectopic spontaneous discharge of injured nerves in the CCI rat model

[0019] Injured nerves in animal models of chronic constriction injury (CCI) can produce ectopic spontaneous discharges, and the frequency of discharges represents the degree of pain in animals. In this embodiment, the following methods are used to detect the influence of glucosamine on the ectopic spontaneous discharge produced by the injured nerve in the CCI rat model:

[0020] 1. Construction of CCI rat model

[0021] Sprague-Dawley (SD) adult rats (about 200 g in body weight, purchased from Beijing Vidolihua Experimental Animal Company) were injected intraperitoneally with 1% sodium pentobarbital at a dose of 40 mg / kg to make them anesthetized. Expose the sciatic nerve for about 1 cm, and then use No. 0 chrome catgut (No. 0-4, purchased from Davis&Geck Co.) to lightly ligate every 1 mm above the trifurcation. A total of 4 ligation points...

Embodiment 2

[0025] Example 2. Detection of the influence of glucosamine on the sensitivity to heat and pain stimulation of the damaged lateral foot of the CCI model

[0026] Detect the impact of glucosamine on the thermal pain stimulation sensitivity of the injured side foot of the CCI model with the following method: first, construct the CCI rat model with the same method as in Example 1; then divide the CCI rats into an experimental group and a control group, There were 10 rats in each group. The control group: fed 1 mL of pure water by intragastric administration every day after the operation; the experimental group: fed 1 mL of glucosamine with a concentration of 7.5 mg / mL (purchased from Beijing Chemical Reagent Company, Analytical Pure), the two groups of animals were tested for the sensitivity to heat and pain stimulation of the injured lateral foot on the 3rd, 5th, 7th, 9th, 11th, and 13th days after the operation, and the physiological indicators of the experimental rats were test...

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Abstract

An application of aminoglucose in preparing the medicines for remitting chronic pain, especially the nervous chronic pain, is disclosed.

Description

technical field [0001] The invention relates to a new application of glucosamine, in particular to the application of glucosamine in the preparation of medicines for alleviating chronic pain. Background technique [0002] Chronic pain refers to pain that lasts for more than 12 weeks. It can produce painful sensations without any other external stimuli, and mild stimuli can produce intense and persistent severe pain. In addition, some non-noxious stimuli can also cause pain. Can induce pain. According to a survey conducted by the World Health Organization on 26,000 people in 1998, 22% of them complained of persistent pain in the past year. Severe chronic pain is a major problem in clinical medicine as it affects millions of people. Pain perception is often intertwined with autonomic nervous activity, motor response, psychological and emotional response, and pain is easily affected by past experience, with great variability. At present, there are no effective treatment measu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7008A61P25/04
Inventor 蔡国平
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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