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Process for preparing original position of nanometer laminated composite material

A nanocomposite material and in-situ preparation technology, applied in the field of in-situ preparation of nanocomposite materials, can solve the problems of unsuitable adsorption and loading, limited content, etc., and achieve the effect of obvious temperature response performance

Inactive Publication Date: 2009-09-02
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] After searching the prior art documents, it was found that "Advanced Functional Materials" ("Functional Frontier Materials"), in 2005, No. 15, "One-step synthesis of highly ordered mesoporous silica Monoliths with metal oxide nanocrystals" reported on page 1377 in their channels" ("one-step synthesis of mesoporous silica bulk with metal oxide nanocrystals in the channels"): This method is based on the interaction of metal ions with -O- groups in block copolymers to form obtained from the assembly of complexes, nano-Fe 2 o 3 Closely arranged in the pores of silica, forming a filament-like morphology, the water solubility of the magnetic precursor used leads to a limited content of iron oxide in the assembled composite material. Since no magnetic test results are provided, it is uncertain whether the final material is magnetic or not. know
Simultaneously formed nano-ferric oxide occupies the pores, and the resulting composite material has a pore size of only 5.2-5.9nm, which is not suitable for the adsorption and loading of larger molecules.

Method used

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  • Process for preparing original position of nanometer laminated composite material
  • Process for preparing original position of nanometer laminated composite material
  • Process for preparing original position of nanometer laminated composite material

Examples

Experimental program
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Effect test

Embodiment 1

[0024] see figure 1 The process flow shown. 1 part of copolymer P123 (EO 20 PO 70 EO 20 ) was added to 120mL of 2M hydrochloric acid solution, and stirred at 40°C for 2h until it was completely dissolved. Then, slowly add 1 part of carbonyl iron Fe(CO) 5 (chemically pure), and stirred for 1h. Then, under the condition of constant stirring, 4 parts of tetraethyl orthosilicate (TEOS) was added, and after stirring at 45° C. for 24 hours, it was moved to an oven at 80° C. for 24 hours. After filtration, the obtained precipitate was dried at room temperature, then transferred to a muffle furnace at 500°C for calcination for 6 hours, and then the obtained brown powder was heat-treated in a vacuum furnace at 450°C for 4 hours, and finally the magnetic medium was obtained. Porous silica I-SBA composites.

[0025] Completely dissolve 1 / 10 part (eg 0.2g) of isopropylacrylamide (NIPA), a certain amount of azobisisobutyronitrile (AIBN) and N,N'-methylenebisacrylamide in 2mL of alco...

Embodiment 2

[0027] 5 parts of copolymer P123 (EO 20 PO 70 EO 20 ) into 2M hydrochloric acid solution, and stirred at 50°C for 2h until it was completely dissolved. Then, slowly add 5 parts of carbonyl iron Fe(CO) 5(chemically pure), and stirred for 1h. Then, under the condition of constant stirring, 8 parts of tetraethyl orthosilicate (TEOS) was added, and after stirring at 50° C. for 24 hours, it was moved to an oven at 90° C. for 24 hours. After filtration, the obtained precipitate was dried at room temperature, then transferred to a muffle furnace at 550°C for calcination for 6 hours, and then the obtained brown powder was heat-treated in a vacuum furnace at 480°C for 4 hours, and finally the magnetic medium was obtained. Porous silica I-SBA composites.

[0028] Dissolve 2 parts of isopropylacrylamide (NIPA), azobisisobutyronitrile (AIBN) and a small amount of N,N'-methylenebisacrylamide in 40mL of alcohol, slowly add 10g of the above-prepared In the magnetic silica material I-SB...

Embodiment 3

[0030] 4 parts of copolymer P123 (EO 20 PO 70 EO 20 ) was added to 2M hydrochloric acid solution, and stirred at 30°C for 2h until it was completely dissolved. Then, slowly add 4 parts of carbonyl iron Fe(CO) 5 (chemically pure), and stirred for 1h. Then, under the condition of constant stirring, 6 parts of tetraethyl orthosilicate (TEOS) was added, and after stirring at 30° C. for 24 hours, it was moved to an oven at 70° C. for 24 hours. After filtration, the obtained precipitate was dried at room temperature, then transferred to a muffle furnace at 450°C for calcination for 6 hours, and then the obtained brown powder was heat-treated in a vacuum furnace at 420°C for 4 hours, and finally the magnetic medium was obtained. Porous silica I-SBA composites.

[0031] Completely dissolve 1 part of isopropylacrylamide (NIPA), a certain amount of azobisisobutyronitrile (AIBN) and a small amount of N, N'-methylenebisacrylamide in 20mL of alcohol, slowly add 5g of the above In the...

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Abstract

The present invention is in-situ process of preparing nanometer composite material, and belongs to the field of composite material preparing technology. The in-situ preparation process of nanometer composite material includes the following steps: 1. dissolving block copolymer in 2M hydrochloric acid solution, adding precursor Fe(CO)5 slowly via stirring, adding ethyl silicate, filtering, drying the precipitant, calcining in a muffle furnace and heat treating the obtained brown powder in a vacuum furnace; and 2. treating polyisopropyl acrylamide through a cyclic 'freezing-degasing-defrosting' process , heating to react, flushing obtained dark brown powder with alcohol, filtering, drying, etc. By means of the self-assembling process of mesoporous material, nanometer composite material possessing magnetic performance and temperature stimulation responding performance and capable of being used as medicine carrier is prepared.

Description

technical field [0001] The invention relates to a preparation method in the technical field of composite materials, in particular to an in-situ preparation method of nanocomposite materials. Background technique [0002] The mesoporous silica drug delivery system with magnetic function has potential applications in many aspects such as site-controlled release. It can guide drugs to diseased tissues to achieve site-specific drug release. It has been reported that the release of genes in mesoporous materials is controlled by using magnetic iron oxides as gates. Lin et al. reported the MCM-41 drug release system using superparamagnetic ferric oxide nanoparticles as a cap-shaped control switch. Other researchers have reported mesoporous silica composites using commercially available magnetic nanoparticles as cores as carrier materials for bioseparation and catalysts. However, these reported systems are basically based on mesoporous MCM-41 with a pore diameter of only 2-4 nm, w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/46A61K47/02A61K47/34B01J32/00
Inventor 朱申敏张荻
Owner SHANGHAI JIAOTONG UNIV
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