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Polyene phosphatidyl choline infusion solution and its preparing method

A technology of polyene phosphatidyl choline and large infusion solution is applied in the directions of drug delivery, pharmaceutical formulations, and medical preparations containing active ingredients, which can solve problems such as drugs with low side effects, and achieve the effect of stable and feasible preparation process.

Inactive Publication Date: 2008-06-11
AOLING BODA MEDICINE SCI & TECH DEV BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many kinds of drugs for the prevention and treatment of liver diseases, but there are few drugs with good curative effect and low side effects, especially the broad-spectrum drugs that are effective for various liver diseases

Method used

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  • Polyene phosphatidyl choline infusion solution and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 (specification: 50ml: 232.5mg)

[0037] Weigh 130g of deoxycholic acid, add it to 10000ml of water for injection, add 1mol / L NaOH solution while stirring to dissolve it, weigh 45g of benzyl alcohol, add it to the above solution, and after stirring, accurately weigh polyene phosphatidyl Choline 250g and sodium sulfite 3g, feed, stir to disperse evenly, adjust the pH value to 8.0 with 1mol / L HCI, add 1.5g nicotinamide, 10g sodium pantothenate, stir and dissolve to obtain solution 1, weigh 2500g xylitol, add 15000ml of water for injection, heated and dissolved to obtain solution 2, mixed solution 1 and solution 2, stirred evenly, added water for injection to 50000ml, added activated carbon, heated and stirred for 30 minutes, filtered to obtain a crude filtrate, and then added 0.4g of vitamin B 2 and 0.025g vitamin B 12 , stirring and dissolving to obtain an intermediate product, which is filtered through a 0.25um microporous membrane after passing the inspection...

Embodiment 2

[0038] Example 2 (specification: 100ml: 465.0mg)

[0039] Weigh 260g of deoxycholic acid, add it to 10000ml of water for injection, add 1mol / L NaOH solution while stirring to dissolve it, weigh 90g of benzyl alcohol, add it to the above solution, and after stirring, accurately weigh polyene phosphatidyl Choline 500g and sodium sulfite 6g, feed, stir to disperse evenly, adjust pH value to 8.1 with 1mol / L HCI, add 3g nicotinamide, 20g sodium pantothenate, stir and dissolve to obtain solution 1, weigh 5000g xylitol, add 20000ml Water for injection, heat and dissolve to obtain solution 2, mix solution 1 and solution 2, stir evenly, add water for injection to 100,000ml, add activated carbon, heat and stir for 30 minutes, filter to obtain a crude filtrate, and then add 0.8g of vitamin B 2 and 0.05g vitamin B 12 After stirring and dissolving, the intermediate product is obtained. After passing the inspection, it is filtered with a 0.2 μ m microporous membrane, filled and sterilized....

Embodiment 3

[0040] Example 3 (specification: 250ml: 1162.5mg)

[0041] Weigh 650g of deoxycholic acid, add it to 80000ml of water for injection, add 1mol / L NaOH solution while stirring to dissolve it, weigh 225g of benzyl alcohol, add it to the above solution, and after stirring, accurately weigh polyene phosphatidyl Choline 1250g and sodium sulfite 15g, feed, stir to disperse evenly, adjust pH value to 8.3 with 1mol / L HCI, add 7.5g nicotinamide, 50g sodium pantothenate, stir and dissolve to obtain solution 1, weigh 12500g xylitol, add 80,000ml of water for injection, heated and dissolved to obtain solution 2, mixed solution 1 and solution 2, stirred evenly, added water for injection to 250,000ml, added activated carbon, heated and stirred for 30 minutes, filtered to obtain a crude filtrate, and then added 2.0g of vitamin B 2 and 0.125g vitamin B 12 , stirring and dissolving to obtain an intermediate product, which is filtered through a 0.3um microporous membrane after passing the inspec...

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Abstract

The present invention belongs to the field of medicine preparation technology, relates to medicine preparation for treating several kinds of liver and gallbladder diseases and its preparation, and is especially one kind of polyene phosphatidyl chloine infusion solution and its preparation process. The preparation process of the polyene phosphatidyl chloine infusion solution includes: adding polyene phosphatidyl chloine, co-solvent, pH regulator, antioxidant and other supplementary material into injection water; regulating pH value to 6.5-10.0; adding active carbon and filtering, adding vitamins to obtain intermediate; content meat, filtering with 0.1-0.45 micron membrane and packing. The stability test shows that the preparation process is stable and feasible; and the safety test shows that the polyene phosphatidyl chloine infusion solution has no allergic reaction, no hemolysis effect, and no irritation on blood vessel.

Description

technical field [0001] The present invention relates to polyene phosphatidylcholine large infusion and its preparation method, in particular to a method for treating various types of liver diseases; bile obstruction; poisoning; prevention of recurrence of gallstones; pregnancy poisoning; psoriasis, neurodermatitis, radiation A pharmaceutical preparation for diseases such as syndrome and a preparation method thereof belong to the technical field of pharmaceutical preparation. Background technique [0002] Hepatitis can be divided into many types due to different pathogenesis, such as viral hepatitis, drug-induced hepatitis (toxic hepatitis), bacterial hepatitis, etc.; , Viral hepatitis caused by hepatitis C, D, and E viruses. Its clinical manifestations all have the common characteristics of strong infectivity, long course of disease and great harm, and the probability of transforming into chronic hepatitis is also relatively high. [0003] my country is a country with a la...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/6615A61K9/08A61P1/16A61P15/00A61P17/06A61P17/00A61P43/00
Inventor 庄洪波
Owner AOLING BODA MEDICINE SCI & TECH DEV BEIJING
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