An extract of faeces bombycis

Abstract

The present invention relates to an extract of Faeces Bombycis, the preparation method thereof, and its use for the preparation of agents or phamaceuticals for diagnosing and treating malignant tumours, as well as an apparatus for diagnosing or treating early stage malignant tumours. The aqueous solution of the extract can emit characteristic fluorescent light of 660nm ± 15nm when it is excited by a light source of 365nm ± l5nm. The extract is produced by saponifing Faeces Bombycis, and then followed by extraction, acidification and salification. In this apparatus, the UV light from a light source (l) is filtered by the Filter (20) and then respectively transmitted by an optic fibre to the end (8) of an incident optic fibre (4) located in a target tissue (7) and the detector (9) of a monitoring unit (3), the input end (10) of a collecting optic fibre(5) receives the fluorescence from the target tissue (7), the output end (12) of the collecting optic fibre is connected to the photomultipler tube (13) in the monitoring unit (3) for detecting the fluorescence intensity, the signals from the tube (13) is processed and displayed on the fluorescence display window (15).

Description

field of invention [0001] The present invention relates to an extract of silkworm excrement, its preparation method, and its use in the preparation of reagents or drugs for diagnosis or treatment of malignant tumors, especially early-stage malignant tumors, and a method for diagnosing or treating malignant tumors, especially early-stage malignant tumors. Tumor device. Background technique [0002] Since the 1970s, it has been proved that there is a characteristic fluorescence in malignant tumor tissue that is different from the autofluorescence of normal tissue. Scientists try to observe and record the characteristic fluorescence of tumor tissue with a fluorescence spectrometer to identify and diagnose malignant tumors. [0003] Cai Chengxi of the University of Tsukuba and others believe that under the excitation of the 5145A argon ion laser as the excitation light source, normal specimens and specimens containing tumor cells produce different characteristic fluorescence, an...

AI Technical Summary

Problems solved by technology

[0018] However, in the pretreatment process of the above methods, organic solvent extraction is used, and then further degradation and treatment will affect the comprehensive properties of the product such as affinity and retention in the tissue.

In addition, the optimal excitation wavelength of the silkworm excrement extract in the prior art is around 405nm. In order to effectively excite the photosensitizer, an excitation light source that can generate light around 405nm is required, which limits the use. A new type of photosensitizer with high concentration and appropriate excitation wavelength is very meaningful for early diagnosis and timely treatment of cancer

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