Azithromycin dripping pill and its prepn

Abstract

The present invention discloses one kind of antibiotic medicine, and aims at providing one kind of orally taken azithromycin dripping pill with high bioavailability, fast medicine release, fast acting, high medicine content, easy taking, low cost and production process without pollution. The azithromycin dripping pill is prepared with azithromycin as medicine material and medicine carrier as matrix.

Description

Technical field [0001] The invention relates to an antibiotic medicine, in particular to an oral preparation prepared from azithromycin as a raw material. Background technique [0002] Azithromycin is a new generation of macrolide antibiotics. Nitrogen is added to the 9th position of the lactone ring. The chemical structure is more stable than erythromycin. The half-life is about 40 hours. The tissue permeability is good (the concentration in the tissue can exceed the serum concentration. 10 to 100 times of that), and a broad antibacterial spectrum, effective against gram-positive bacteria, gram-negative bacteria, mycoplasma, and chlamydia. In addition, azithromycin for injection overcomes the shortcomings of low bioavailability (about 37%) of its oral preparations, especially for the treatment of severe infections, making its clinical application more extensive. In terms of clinical efficacy, the therapeutic effects of azithromycin citrate for injection and azithromycin lactobio...

AI Technical Summary

Problems solved by technology

[0003] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect

In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment

Although injections overcome the disadvantages of low bioavailability of conventional oral preparations, they have the disadvantages of prone to allergic reactions, inconvenient use, and great pain for patients

Furthermore, the production process of conventional oral preparations and injections is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society