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Nanometer emulsion and preparation method thereof

A technology of nanoemulsion and milk homogenizer, which is applied in the field of new dosage forms of drugs to achieve the effect of improving solubility, increasing transdermal absorption rate, and good drug dispersibility

Inactive Publication Date: 2007-09-26
HAINAN PULIN PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But they are two completely different states, and there are essential differences

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: preparation javanica javanica oil nanoemulsion

[0018] Prescription: Brucea javanica oil 100g

[0019] Glycerin 25g

[0020] Soy Lecithin 20g

[0021] Pluronic F68 5g

[0022] Add water for injection to 1000ml

[0023] Full volume 1000ml

[0024] Preparation Process:

[0025] ①. Heat phospholipids, glycerin and javanica javanica oil to 60 degrees, fully stir and disperse evenly;

[0026] ②. Heat Pluronic F68 and appropriate amount of water to 80 degrees to dissolve;

[0027] ③. At a constant temperature of 60 degrees, add the water phase to the oil phase dropwise while stirring;

[0028] ④. Dispersed by high-pressure milk homogenizer for many times, filtered, subpackaged and sterilized.

[0029] The obtained nanoemulsion has an average particle diameter of 65 nanometers, stable quality, improved bioavailability and reduced side effects.

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Abstract

The invention provides a nanometer emulsion which is prepared by, mixing medicament, solvent oil and emulsifying agent, heating up to 60 deg. C, agitating, dispersing homogeneously, heating booster solvent with right amount of water to 80 deg. C for dissolution, keeping the temperature at 60 deg. C, charging aqueous phase into oil phase, high pressure dispersing, filtering, split charging, and sterilizing.

Description

technical field [0001] The invention relates to a new dosage form of medicine, in particular to a preparation method of a nanoemulsion type. Background technique [0002] Some poorly soluble drugs, fat-soluble drugs and some traditional Chinese medicine extracts are poorly absorbed in the human body and have low bioavailability. Generally, they are traditionally made into emulsions, and the emulsion is used as a drug carrier, but the particle size of the oil phase of this traditional emulsion is relatively large, generally greater than 100nm. Ordinary emulsions are thermodynamically unstable systems, and energy is required for preparation. After delamination, and this emulsion is prone to precipitation during storage, which affects the curative effect of the drug. [0003] Nanoemulsion is an oil-in-water emulsion. The oil phase is mechanically pulverized into the water phase by a high-pressure homogenizer at least once to prepare an emulsion. The p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107
Inventor 范敏华
Owner HAINAN PULIN PHARMA
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