32results about How to "Reduced discrimination" patented technology

Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.

The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′ to 5′ exonuclease activity and/or exhibit reduced discrimination against non-conventional nucleotides relative to the wild-type form of the polymerase.

A flame-retardant and fireproof cigarette which aims to contain the combustion process to the cigarette. The flame-retardant and fireproof cigarette has a filter that is aligned with a tobacco body. A flame-retardant and fireproof covering is positioned over at least a portion of the tobacco body and isolates the open fire associated with the consumption of the tobacco during the course of smoking or burning the cigarettes. Such a cigarette reduces the risk of undesired, inadvertent, and latent ignition of adjacent materials.

The invention discloses a digital signal transmitting method based on modulated carriers of equal amplitude and equal period, comprising the steps of: sampling two basic wave shapes of f0(t) of 0 representation information and f1(t) of 1 representation information within a period; respectively selecting a storage area which corresponds to f0(t) or f1(t) by a control selection switch of binary information to be transmitted within a wave shape period; converting wave shape samples in the storage area into modulated high-frequency simulating signals under the control of a synchronous clock; transmitting the modulated high-frequency simulating signals subjected to up-conversion modulation, filtering and power amplification; and demodulating the modulated signals before up-conversion on a transmitting end by adopting a demodulating method based on small phase difference or a demodulating method based on zero-crossing detection after the down-conversion of the received signals. The invention also discloses special equipment for implementing the method. A high-efficiency modulating system of equal amplitude and equal period realized by the method further enhances frequency band utilization ratio, ensures the constant performance of the amplitude of the modulating wave shapes, and also strengthens the capability of resisting channel distortion and noise disturbance.

The invention relates to compositions and methods utilizing split polymerase enzymes composed of at least two discrete polypeptides that stably associate to form a single polymerase. The invention further relates to nucleic acid constructs for expressing the split polymerases of the invention, and methods for using the split polymerases of the invention. The enzymes of the invention are useful in many applications calling for the detectable labeling of nucleic acids and are particularly useful in quantitative PCR (QPCR) and DNA sequencing applications.

An antenna system comprises an antenna feed support and a driver. The antenna feed support is configured to mount a circularly polarized antenna feed to an antenna dish to extend outward along a longitudinal axis of the circularly polarized antenna feed with respect to a reflective surface of the antenna dish. The driver is configured to rotate the circularly polarized antenna feed to adjust alignment between the circularly polarized antenna feed and a remote antenna. The driver can rotate the circularly polarized antenna feed mechanically, electrically or both to adjust alignment between the circularly polarized antenna feed and a remote antenna to reduce cross-pol discrimination at the circularly polarized antenna feed.

The invention discloses a compound signal transmission and communication method based on an equal-amplitude equal-period modulated carrier wave technology, which comprises two parts, including the compound transmission of an analog signal and digital information and compound information receiving demodulation, wherein the compound transmission of the analog signal and the digital information comprises the following steps of coding an information source, coding a channel, forming a carrier wave, modulating a base band and modulating upper frequency conversion; in the carrier wave formation, a wave shape of a carrier wave is directly changed by a binary system information code element; compared with a standard sinusoidal wave, a modulated wave shape f1(t) generated when an information bit is one and a modulated wave shape generated when the information bit is zero have an adjustable tiny difference; and the compound information receiving demodulation comprises the following steps of demodulating lower frequency conversion, the analog signal and the digital information, decoding the channel and decoding the information source. The method realizes the compound transmission of the analog signal and the digital information and improves the utilization ratio of communication and transmission resources.

The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′ to 5′ exonuclease activity and/or exhibit reduced discrimination against non-conventional nucleotides relative to the wild-type form of the polymerase.

This invention improves the accuracy of wobble signal detection for disc discrimination and reduces discrimination errors due to noise. In an optical disc apparatus, a wobble signal generator creates a wobble signal from an electrical signal which has been obtained from conversion by a pickup. A bandpass filter (BPF) is set to change its central frequency to a wobble frequency f0 and to fn different from the wobble frequency, and the filter extracts the respective frequency components from the wobble signal. An amplitude-measuring section measures amplitude levels A0 and An of the extracted multiple signals. A disc discriminator compares the multiple amplitude levels and if the amplitude A0 is greater than the amplitude An by at least a threshold level Ath, judges that a wobble is present.

An image forming apparatus includes an image bearing member, a developing device, a driving device, and a controller. The developing device includes a developing container, a first feeding member, a second feeding member, a developer carrying member, a content sensor, and a sealing member. When information that the developing device is new is inputted, before an image forming operation is executed, the controller executes an initializing operation for driving the first feeding member and the second feeding member. The controller provides notification to the effect that the sealing member is not removed on the basis of an output of the content sensor during the initializing operation.