The invention provides a central air-conditioning fresh air purification device, including a purification box, an air inlet pipe, a fresh air outlet pipe, a first hollow plate, a second hollow plate, a partition plate, an adjustable locking fixing seat structure, and a rotatable lifting filter frame cover structure , impactable drying frame structure, observable pull-out cleaning box structure, U-shaped slide rail, first fixed cover, second fixed cover, primary filter, negative ion generator, electrostatic precipitator, fresh air fan and high-efficiency filter . The arrangement of the first sealing cover, the rotating rod, the pushing rod, the first filter screen, the L-shaped sliding rod, the threaded fixing pipe and the purification box in the present invention is beneficial to grasp the pushing rod to rotate during work, and fix it by the rotating rod and the screw thread The pipe thread connection is arranged so that the first sealing cover drives the first filter net to move upwards, which is convenient for cleaning and replacing the first filter net during use, and realizes lifting work at the same time.