The invention discloses a human-computer interactive intelligent wheelchair which comprises a wheelchair body, two driving rear wheels, two driven front wheels, a storage battery, two driving motors, a human-computer interactive device, an operation rod and a motor driver, wherein the wheelchair body comprises a table top and two pedals. The human-computer interactive intelligent wheelchair is characterized in that an embedded control system is installed in the table top, a controller of the embedded control system is a 16-bit SPCE016A singlechip, an ultrasonic autonomous navigation mechanism is distributed at the lateral portion of the wheelchair body, and a voice control mechanism and a vision autonomous navigation mechanism are distributed on the wheelchair body. The ultrasonic autonomous navigation mechanism, the voice control mechanism and the vision autonomous navigation mechanism are respectively in telecom connection with the embedded control system which is further in telecom connection with the operation rod and the motor driver, and the storage battery provides power for the driving motors. By mean of the human-computer interactive intelligent wheelchair based on the 16-bit SPCE016A singlechip serving as the controller of the embedded control system, the problems that the existing human-computer interactive intelligent wheelchair based on a universal computer controller has high cost, large power consumption, poor cruising capability and the like can be solved well.