The invention relates to an easily-occurring disease prediction system based on a merdian-collateral energy balance value, which comprises a main and collateral channels acquisition module, a pretreatment module, an easily-occurring disease prediction module, a prediction result processing module and a client terminal, wherein the main and collateral channels acquisition module acquires and analyzes to obtain the energy balance value of twelve main and collateral channels, and transmit to the preprocessing module. The preprocessing module comprises an energy area dividing unit, a merdian-collateral risk pattern map unit and a storage unit, wherein a merdian-collateral risk pattern map table established by the merdian-collateral risk pattern map unit is used for determining a risk pattern and a risk grade of each main and collateral channels, the storage unit assigns a value to the merdian-collateral risk prediction function fi to form a merdian-collateral risk mode set psi; the easily-occurring disease prediction module establishes a easily-occurring symptom prediction model to form a symptom set phi'; a easily-occurring disease prediction model is established to obtain a prediction function value Ri for the easily-occurring diseases in a disease set omega one by one; the prediction result processing module screens and sorts Ri to form a new easily-occurring disease set omega',and a data report is generated in the client terminal.