The invention discloses a high-precision matching model-based method for calculating coronary artery parameters. According to the method, firstly, the angiography imaging means and the intravascular imaging means of a coronary vessel part are acquired. After that, an angiography image and an intravascular image are matched to form a high-precision matching model. The blood flow amount, the blood fractional Flow Reserve (FFR) and the microcirculation resistance index of microcirculatory resistance (IMR) of coronary vessels are calculated on the basis of the high-precision matching model. According to the method for calculating the coronary parameter blood flow, the blood flow reserve score and the microcirculation resistance index, the high-precision matching model of images is acquired through two ways, namely the angiography imaging means and the intravascular imaging means. The calculation result of the method is more accurate than the image of either the angiography imaging means orthe intravascular imaging means alone, so that the method is high in practicability.