High efficiency balanced detection interferometer

Abstract

An interferometer configured for use in optical coherence domain (OCT) reflectometry systems is disclosed. In the preferred embodiments, efficient routing of light and a balanced detection arrangement provide a high signal to noise ratio. In a first set of embodiments, a 3×3 coupler is used to split light along separate sample and reference paths and also for combining light returning from those paths and supplying the interfered collected light to the detection system. In an alternate set of embodiments, a pair of cascaded 2×2 couplers provides a similar function. The interferometer can be used with various OCT modalities including time-domain and frequency domain approaches.

Description

PRIORITY CLAIM PROVISIONAL[0001]This patent application claims priority to U.S. Provisional Patent Application No. 60 / 629,429, filed Nov. 19, 2004, which is incorporated herein by reference.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The invention relates generally to optical imaging using optical coherence tomography and in particular to systems and methods for achieving balanced detection with high signal to noise ratio.[0004]2. Description of Related Art[0005]Optical coherence domain reflectometry (OCDR) is a technique initially developed to provide a higher resolution over optical time domain reflectometry (OTDR) for the characterization of the position and the magnitude of reflection sites in such optical assemblies as optical fiber based systems, miniature optical components and integrated optics (Youngquist et al., “Optical Coherence-Domain Reflectometry: A New Optical Evaluation Technique”, 1987, Optics Letters 12(3):158-160). With the addition of transve...

AI Technical Summary

Benefits of technology

[0113]It should be noted that only one human eye has been measured with both configurations, and only a few images were recorded. The images chosen for analysis here represent the best of their type from among the small set of images available. Nevertheless, the anterior chamber eye section images, together with easily interpreted test eye data, provided strong initial evidence that SNR performance with the embodiment 2 of FIG. 4 of the present invention is better than the performance of the configuration of Ci of FIG. 2.

[0114]Comparative horizontal line scan images of an anterior chamber are displayed in FIG. 12 in which (a) and (b) show respectively the images obtained with the Ci of FIG. 2 and the FIG. 4 configurations. The pixel values have been scaled logarithmically, and a reverse gray scale “colormap” has been used to allow accurate reproductions on white paper with black toner. The images are of the same human subject, and the gray scale has been normalized in each case with respect to the background noise level (the mean of pixel values found in a free space region of the image). Thus, all pixels of the same color in both images represent the same SNR. There are several things to notice in FIG. 12. First, the SNR is stronger throughout the corneal tissue in the FIG. 4 configuration image. Second, the anterior surface layer and the bulk of the crystalline lens are easier to discern. Third, the spot associated with corneal reflex is larger and more intense in the FIG. 4 configuration image. This is because the sensitivity of the instrument to specular reflections from surfaces is now enhanced. To achieve the best contrast at surfaces that are nearly normal to the beam, it may be necessary in the FIG. 4 configuration case to slightly misalign the subject's eye from the reflex alignment. It was possible to resolve the posterior surface of the crystalline lens with contrast comparable to the anterior surface.

[0117]Although data from human subjects provide the most important test of OCT system performance, data taken with a test eye are more easily interpreted and compared. This is because the alignment, geometry, and composition of the test eye is guaranteed to be consistent from scan to scan. FIG. 15 shows horizontal line scan images of a test eye consisting of a vertical plastic tube, in which (a) is the image obtained with the configuration of Ci of FIG. 2 and (b) is the image obtained with the presently invented configuration of FIG. 4. The backscattering from the plastic bulk is roughly comparable to the backscattering from corneal tissue. As with the cornea, the sensitivity to retro-reflection from surfaces is significantly greater with the presently invented configuration of FIG. 4. Since the plastic is a homogeneous “tissue,” the histogram of pixel values for this test eye is a distinctive bimodal distribution. As shown in FIG. 16, the signal from backscattering inside the plastic has a peak that is clearly separated from the noise peak. In the image taken with the presently invented configuration of FIG. 4, the center of the signal peak is at a pixel value that is 2 dB larger than in the image of configuration Ci of FIG. 2. This indicates that the average SNR for the plastic is about 2 dB better with the present invention image.

[0120]It should be highlighted that the configurations of the present invention are relatively simple and compact when compared to prior art configurations. In addition to general optical interferometry for various applications, such as distance measurement, topography and three dimensional measurement of a volume sample, the present invention is particularly beneficial for application in various optical coherence tomography schemes, including time domain OCT, spectral domain OCT and swept source OCT. In the latter two cases, the optical delay line does not need to be scanned. Alternatively, the optical delay line may be used to achieve phase tracking or a π phase shift dithering of the optical path length and hence to realize differential spectral interferometry.

Problems solved by technology

However, this configuration is limited to an optical efficiency of 25% as explained below.

Otherwise, the signal will be degraded by the optical power noise of the source.

Hence virtually 75% of the optical power supplied by the light source is wasted in this configuration.

Another issue with the classic Michelson interferometer (FIG. 1) is that light from the reference arm is coupled back into the optical source, causing side effects that can impact the quality of the resulting image.

However, due to the fact that a practical fast-scanning optical delay line operates in reflection mode, a second circulator is needed, and this will increase the cost of the system.

However, in the case of Ai and Aii, although the SNR is maximized, if a retroreflective ODL is desired in these configurations, a second circulator would be necessary which will increase the cost of the system.

The system hence costs more and is not very compact.

For the cases of Ci and Cii, although the system is compact as there is only one 2×2 coupler, the optical power efficiency is not fully maximized as the power splitting ratio of the coupler must be made 50 / 50 for returned dual balanced detection, which will also force the forward split ratio to be 50 / 50.

As a result, attenuation in the reference arm is needed to achieve shot noise limited detection and this will waste optical power.

But these schemes generally require a complicated polarization dependent splitter design and are not very suitable for biological samples with varying birefringence [EP1253398, U.S. patent Application No.

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