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Cosmetic material containing triple- encapsulated retinol

a technology of retinol and stabilized retinol, which is applied in the direction of biocide, drug composition, animal husbandry, etc., can solve the problems of reducing the elasticity of skin, general degradation of skin, and affecting the skin, and achieves stable retinol, improved affinity to skin, and stabilized first-stabilized retinol

Inactive Publication Date: 2005-06-21
COREANA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is a method for stabilizing unstable fat-soluble cosmetically active materials, such as retinol, with a combination of nonionic surface-active agents, cholesterol, phytosterol, and sphingosome. The method involves a three-layer trapping system that effectively stabilizes retinol against air, water, and heat. The triple layers consisting of lecithin, ceramide, and cholesterol improve the affinity and permeability of the retinol to the skin, resulting in a long-lasting and effective treatment with minimal skin irritation.

Problems solved by technology

Chronoaging results in general degradation of the skin.
Wrinkling and thickening of the skin induced by solar light result in sagging, reduced elasticity of skin, dry skin and mottling, and other harmful effects are additively increased by exposure to sunlight and this phenomenon is called “photoaging”.
Also, pure retinal induces skin irritation even when used in small amounts.
Due to these drawbacks, retinal has been limitedly incorporated into cosmetic formulations.
This technique stabilizes doubly retinal, however the second-encapsulating with gellan gums is a kind of an open matrix system, therefore this method is limitedly effective in protecting retinal from oxygen, air or heat.
However the only difference between patent techniques is the kind of chelating agents and properties of antioxidants used, so with these methods, retinol cannot be protected from oxygen, moisture or heat effectively.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Production of Nonionic Surface-active Agent Vesicle

[0033]

TABLE 1Composition of nonionic surface-active agent vesicle.unit: weight %Example 1-1Example 1-2Example 1-3ACholesterol3.008.008.00phytosterol5.005.005.00choleth-243.505.002.00ceteth-24——2.00steareth-41.503.002.00dicetylphosphate1.005.003.00capryliccaprictriglyceride10.0018.0018.00Bpurified waterTo 100To 100To 100glycerine5.005.005.00Cretinol 50%10.0020.0015.00(in polysorbate 20)Total100100100

Synthesis Procedure[0034]The chemicals of A-phase are all mixed and heated to 70˜80° C.[0035]The A-phase mixture must be perfectly homogeneous.[0036]The chemicals of B-phase are all mixed and heated to 70˜80° C.[0037]Then B-phase mixture is added into A-phase mixture.[0038]The A,B-phase mixture is then stirred.[0039]After the mixture is cooled sufficiently, Chemicals of C-phase are added into the A,B-phase mixture at low temperature.[0040]The total mixed compound is passed through a high-pressure emulsifier.[0041]Finally vesicles, which h...

example 2

Production of Sphingosomes

[0042]

TABLE 2Composition of sphingosomesunit: weight %Example 2-1Example 2-2Example 2-3Ahydrogenated lecithin3.006.00—lecithin——8.00ceramide (03)0.500.700.50capryliccapricglyceride7.0010.0010.00Bpropyleneglycol10.0015.0010.00ethanol5.0010.0010.00purified waterTo 100To 100To 100Cnonionic surface-active30.0050.0040.00agent vesticle(Example 1-2)Dmacadamia nut oil20.0030.0020.00jojoba oil——10.00Total100.00100.00100.00

Synthesis Procedure[0043]The chemicals of A-phase are all mixed, heated to 80-90° C. and melted.[0044]Chemicals of B-phase are added into the A-phase mixture.[0045]The A,B-phase mixture is passed through a high pressure emulsifier.[0046]Chemicals of C-phase are added into the A,B-phase mixture and the A,B,C-phase mixture is passed through a high pressure emulsifier.[0047]Chemicals of D-phase are all added into the former mixture.[0048]The total mixture is stirred and passed through a high pressure emulsifier.[0049]Thereby, sphingosomes are produced...

example 3

Production of Emulsifying Base

[0050]

TABLE 3Composition of emulsifying baseunit: weight %ExampleExampleExample3-13-23-3AParaffin1.51.51.5glyceryl stearate2.52.52.5stearyl alcohol2.52.52.5stearic acid1.01.01.0trioctanoin5.05.05.0squalene5.05.05.0liquid paraffin3.03.03.0stearyl glucoside2.5—1.5polyglyceryl-3-—2.51.5methylglucosedistearatecholesterol0.50.50.5ceramide0.50.50.5tocopheryl acetate0.50.50.5BHT0.10.10.1Cyclomethicone1.01.01.0Bpurified waterTo 100To 100To 100glycerine5.05.05.0sorbitol2.02.02.0xanthan gum0.050.10.1triethanol amine0.50.50.5aroma, antisepticproper quantityproper quantityproper quantityCsphingosome2.02.02.0(Example 2-2)Total100100100

Synthesis Procedure[0051]Chemicals of A-phase and Chemicals of B-phase are mixed, heated and melted to 75° C.[0052]A-phase mixture is added into B-phase mixture.[0053]The A,B-phase mixture is cooled to 40° C.[0054]Chemicals of C-phase are added into the A,B-phase mixture and the total mixture is cooled to room temperature.

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Abstract

The present invention concerns stabilized cosmetic material containing triple-encapsulated retinol. Unstable, fat-soluble retinol is stabilized firstly by addition into vesicles consisting of nonionic surface-active agent, cholesterol and cholesteryl ester. The firstly stabilized retinol(vesicle) is subsequently inserted into sphingosomes (a kind of multi lamellar liposome) consisting of lecithin and ceramide. Finally the double-encapsulated retinol (sphingosome) is inserted into lamellar liquid-crystal emulsifying base, thereby being triply encapsulated.

Description

FIELD OF THE INVENTION[0001]The present invention concerns stabilized cosmetic material containing triple encapsulated retinol. In concrete terms, unstable and fat-soluble retinol is stabilized firstly by addition into vesicles consisting of nonionic surface-active agent, cholesterol and cholesteryl ester. The firstly stabilized retinol(vesicle) is subsequently inserted into sphingosomes (a kind of multi lamellar liposome) consisting of lecithin and ceramide. Finally the double encapsulated retinol(sphingosome) is added into a lamellar liquid-crystal emulsifying base. Thusly, useful cosmetic material, which diminishes wrinkling, skin irritation and improves moisturizing effect, is obtained.BACKGROUND OF THE INVENTION[0002]Chronoaging results in general degradation of the skin. Wrinkling and thickening of the skin induced by solar light result in sagging, reduced elasticity of skin, dry skin and mottling, and other harmful effects are additively increased by exposure to sunlight and ...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K8/68A61K8/63A61K8/55A61K8/67A61K8/30A61K31/045A61K31/07A61K8/02A61K8/14A61K8/11A61Q19/08A61K8/00A61K8/31A61K8/34A61K8/36A61K8/37A61K8/39A61K8/42A61K8/58A61K8/60A61K8/72A61K8/73A61K8/89A61K8/891A61K8/96A61K8/97A61K8/98A61Q19/00
CPCA61K8/0295A61K8/14A61K8/55A61K8/553A61K8/63A61K8/671A61K31/07A61Q19/08A61K8/68Y10S514/937A61K2800/412A61K2800/52Y10S514/887A61K8/34
Inventor LEE, SEUNG JIJO, BYOUNG KEELEE, YOUNG JINLEE, CHUN MONG
Owner COREANA COSMETICS
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