Yarns and fibers of poly(butylene succinate) and copolymers thereof, and methods of use therof

Abstract

Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially / fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of and priority to U.S. Application No. 62 / 636,930 , filed Mar. 1, 2018 and U.S. Application Ser. No. 62 / 733,384 , filed on Sep. 19, 2018, which is hereby incorporated herein by reference in their entirety.FIELD OF THE INVENTION[0002]The present invention generally relates to multifilment yarns and monofilaments fibers made from resorbable polymeric compositions and methods of using them. The yarns and fibers contain poly(butylene succinate) and copolymers thereof.BACKGROUND OF THE INVENTION[0003]Multifilament products made from resorbable polymers, such as copolymers of glycolide and lactide, and monofilament products made from resorbable polymers, such as polydioxanone (PDO), are well known in the prior art, and widely used in wound closure and general surgery. However, these products undergo rapid loss of strength retention in vivo, which limits their application primarily to fast healing repairs, an...

AI Technical Summary

Benefits of technology

The patent describes a type of surgical mesh made from oriented fibers of poly(butylene succinate) and copolymers thereof. These meshes are designed to prevent additional tension being placed on tissues at the implant site and maintain the original area of reinforcement or repair. Additionally, the meshes do not curl along their edges after implantation, which can result in tissue damage. The implants can also contain antimicrobial agents to prevent colonization and infection after implantation. Other embodiments include coverings and receptacles made from the same materials as the meshes, which can hold, or partially or fully cover, devices such as pacemakers, breast implants, and neurostimulators. These implants are sterilized by irradiation, but are more preferably sterilized by ethylene oxide gas or cold ethylene oxide gas.

Problems solved by technology

Pig tailing of suture fibers is undesirable because it makes the handling of surgical sutures very difficult during implantation.

Pitting of the surface of a small diameter fiber, or uneven erosion of the fiber surface, can result in the premature loss of strength retention of the fiber leading to early failure of the fiber in vivo.

Premature loss of strength retention results from the effective cross-section of the fiber being decreased by pitting.

Curling of implantable mesh along its edges is undesirable because it can expose neighboring tissue to mesh edges and result in tissue damage.

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