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Use of dhea or precursors or metabolic derivatives thereof as a depigmenting agent

a technology which is applied in the field of use of dhea or precursors or metabolic derivatives thereof as a depigmenting agent, can solve the problems of difficult or even hazardous use, non-uniform skin, etc., and achieve the effect of improving the homogeneity of skin color

Inactive Publication Date: 2008-07-03
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

DHEA effectively reduces skin pigmentation with low concentrations, improving skin color homogeneity and treating conditions like actinic lentigo without the side effects of traditional agents, while also being safe for use on hair.

Problems solved by technology

In addition, at different periods in their life, certain individuals develop darker and / or more colored blemishes on the skin and more especially on the hands and the neck and shoulders, making the skin non-uniform.
Although they have a certain level of efficacy, these compounds are, unfortunately, not free of side effects on account of their toxicity, which can make them difficult or even hazardous to use.
This toxicity arises from the fact that they interfere with fundamental mechanisms of melanogenesis by killing cells which then risk disrupting their biological environment and which consequently force the skin to eliminate them by producing toxins.
However, it has never yet been suggested that DHEA or at least one of its precursors or derivatives might have regulatory activity on pigmentation by acting directly on melanogenesis.

Method used

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  • Use of dhea or precursors or metabolic derivatives thereof as a depigmenting agent

Examples

Experimental program
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Effect test

example 1

Composition Based on DHEA

[0062]The composition below, in which the proportions of the various constituents are indicated as percentages by weight, was prepared:

DHEA2%Propylene glycol isostearate13% Polyethylene glycol (8 EO)5%Propylene glycol3%Pentylene glycol3%Glyceryl stearate and polyethylene glycol5%stearate (100 EO)oxyethylenated sorbitan monostearate (20 EO)0.5%  Oxyethylenated (20 EO) oxypropylenated (5 PO)cetyl alcohol1%Gelling agents0.5%  C12-15 alkyl benzoates4%Ethanol3%Sodium hydroxide0.12%  Preserving agents0.7%  Waterqs 100% 

example 2

Demonstration of the Depigmenting Activity of DHEA

[0063]a-Protocol

[0064]A gelled oil-in-water emulsion, containing 1% by weight of DHEA as sole active agent, was tested on a group of 20 women from 55 to 70 years old. The emulsion was applied morning and evening for four months to the back of one hand.

[0065]The marks present on the skin were evaluated before and after treatment by visual observation made by an expert, giving the marks an overall score from 0 to 7 as a function of their number, their size and their intensity (clinical evaluation).

[0066]They were also evaluated by colorimetry, using a Minolta CR200 chronometer (biophysical evaluation). This apparatus describes the colors in a three-dimensional space, using the system of coordinates L, a* and b* recommended by the International Commission on Illumination, in which L* represents the luminance or clarity of the color (O corresponding to white and 100 to black), a* is the separation component between green (negative) and r...

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Abstract

The use of DHEA or at least one of its biological precursors or of its metabolic derivatives in or for the manufacture of a composition for topical application to the skin, as a pigmentation regulator for the skin or its superficial growths, especially as a depigmenting and / or bleaching agent for the skin, in particular in the treatment of pigmentation marks, and as a pro-pigmenting agent for superficial body growths.

Description

BACKGROUND OF THE INVENTION[0001]1. Field of the Invention[0002]The present invention relates to the use of DHEA or at least one of biological precursor thereof or metabolic derivative thereof in or for the manufacture of a composition for topical application to the skin, as a pigmentation regulator for the skin or its superficial growths, especially a depigmenting and / or bleaching agent for the skin, in particular, for the treatment of pigmentation marks.[0003]2. Description of the Background[0004]The color of human skin depends on a variety of factors and, in particular, the seasons of the year, race and sex, and it is mainly determined by the nature and concentration of melanin produced by the melanocytes. Melanocytes are specialized cells which synthesize organized melanin by means of specific organelles, the melanosomes. In addition, at different periods in their life, certain individuals develop darker and / or more colored blemishes on the skin and more especially on the hands ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/63A61K31/56A61Q19/02A61Q17/04A61K8/00A61K8/30A61K8/33A61K8/35A61K8/36A61K8/362A61K8/365A61K8/368A61K8/37A61K8/40A61K8/41A61K8/46A61K8/49A61K8/55A61K8/58A61K8/60A61K8/67A61K8/73A61K8/89A61K8/96A61K8/97A61K31/568A61K31/5685A61K31/57A61K31/575A61P17/00A61P17/12A61P43/00A61Q5/00A61Q5/08A61Q5/10A61Q19/00A61Q19/08C07J1/00C07J7/00C07J9/00
CPCA61K8/35A61K8/368A61K8/37A61K8/40A61Q19/02A61K8/4946A61K8/585A61K8/63A61Q19/00A61K8/466A61P17/00A61P17/12A61P43/00
Inventor DE LACHARRIERE, OLIVIERNOUVEAU, STEPHANIE
Owner LOREAL SA
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