Compositions and methods of delivery of pharmacological agents
a technology of pharmacological agents and compositions, applied in the field of pharmaceutical compositions, can solve the problems of phlebitis, burning and pain, venous irritation, parenteral use, etc., and achieve the effects of reducing one or more side effects, and inhibiting microbial growth
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example 1
[0051] This example demonstrates the preparation of pharmaceutical compositions comprising paclitaxel and albumin. Preparation of paclitaxel-albumin compositions is described in U.S. Pats. 5,439,686 and 5,916,596, which are incorporated in their entirety by reference. Specifically, 30 mg of paclitaxel was dissolved in 3.0 ml methylene chloride. The solution was added to 27.0 ml of human serm albumin solution (2% w / v). Deferoxamine was added as necessary. The was homogenized for 5 mmutes at low RPM (Vitris homogenizer, model Tempest I.Q.) in order to form a crude emulsion, and then transferred into a high pressure homogenizer (Avestin). The emulification was performed at 9000-40,000 psi while recycling the emulsion for at least 5 cycles. The resulting system was transfenred into a rotary evaporator, and methylene chloride was rapidly removed at 400° C., at reduced pressure (30 mm Hg) for 20-30 minutes. The resulting dispersion was translucent, and the typical average diameter of the ...
example 2
[0053] This example demonstrates the preparation of a phmaceutical composition comprising amiodarone and albumin. 30 mg of amiodarone was dissolved in 3.0 ml methylene chloride. The solution was added to 27.0 ml of human serum albumin solution (1% w / v). Deferoxamine was added as necessary. The mixture was homogenied for 5 minutes at low RPM (Vitis homogenizer, model Tempest I.Q.) in order to form a crude emulsion, and then transferred into a high pressure homogenizer (Avestin). The emulisification was performed at 9000-40,000 psi while reycling the emulsion for at least 5 cycles. The resulting system was tansferred into a rotary evaporator, and methylene chloride was rapidly removed at 40° C., at reduced pressure (30 mm Hg) for 20-30 minutes. The resulting dispersion was translucent, and the typical average diameter of the resulting amiodarone particles was in the range 50-220 nm (Z-average, Malvern Zetasizer). The dispersion was further lyophilized for 48 hr. The resulting cake was...
example 3
[0055] This example demonstrates the preparation of pharmaceutical compositions comprising liothyronine and albumin compositions. Liothyronine (or suitable salt) was dissolved in an aqueous alcoholic solution or alkaline solution at a concentraion of 0.5-50 mg / ml. The alcoholic (or alkaline) solution was added to an albumin solution (0.1- 25% w / v) and agitated. Agitation was low shear with a stirrer or high shear using a sonicator or a homogenizer. At low concentrations of liothyronine, (5- 1000 μg / ml) clear solutions were obtained. As the concentration was increased, a milky stable suspension was obtained. These solutions or suspensions were filtered through a sterilizing filter. Organic solvents were removed by evaporation or other suitable method.
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