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Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces

a tissue surface and physiologic agent technology, applied in the field of enhanced delivery of physiologic agents to tissue surfaces, can solve problems such as cranial blood vessel restriction, and achieve the effects of preventing or preventing the progression of migraine episodes, and facilitating the onset of action rapid

Inactive Publication Date: 2006-08-03
CAPNIA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0014] In preferred protocols, at the onset of a migraine headache, the patient would take a dose of the vasoconstrictive agent and substantially simultaneously initiate delivery of the capnic gas to the target membrane. The capnic gas would provide a rapid onset of action, possibly by inhibiting the release of CGRP as described above, in order to interrupt or delay progression of the migraine episode. At the same time, the circulating plasma levels of the vasoconstrictive agent would increase, resulting in constriction of the cranial blood vessels. The patient would experience a more effective treatment in one of several ways. As the capnic gas would at least slow the progression of the migraine, the migraine would be less intense at the time effective plasma levels of the vasoconstrictive agent have been achieved. The magnitude of pain and associated symptoms experienced by the patient should be lessened at all points during the treatment. In other cases, the patient might benefit by reducing the dosage of the vasoconstrictive agent and thereby reducing side effects.

Problems solved by technology

At the same time, the circulating plasma levels of the vasoconstrictive agent would increase, resulting in constriction of the cranial blood vessels.

Method used

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  • Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces
  • Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces
  • Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces

Examples

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Embodiment Construction

[0024] An exemplary carbon dioxide dispenser 100 comprising a carbon dioxide cartridge 101 is illustrated in FIG. 1. The embodiment of FIG. 1 is described in greater detail in parent application Ser. No. 09 / 708,186, now U.S. Pat. No. 6,959,708, the full disclosure of which has previously been incorporated herein by reference. A user delivers a dose of carbon dioxide or other treatment gas, referred to generally as “capnic gases” (optionally carrying the vasoconstrictive agent to be delivered) by applying the top of the dispenser 608 to the user's nose or mouth and pushing a button 600 which releases an internal mechanism to allow the CO2 to flow from the top of the dispenser 608. The internal mechanism will lower the pressure of CO2 in the cartridge and will control the flow rate within suitable ranges, typically from 0.5 to 30 cc / sec. The flow rate may be maintained for a suitable time period, typically at least 2 seconds when suffusing the nasal and sinus passages. The device is c...

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Abstract

Apparatus and methods deliver vasoconstrictive agents simultaneously with capnic gases. The capnic gases can enhance the effectiveness of the vasoconstrictive agent, lower the dosage of drug or concentration of agent necessary to achieve a therapeutic result, or both. Exemplary capnic gases include carbon dioxide, nitric oxide, nitrous oxide, and dilute acid gases.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS [0001] This application is a continuation-in-part of U.S. application Ser. No. 11 / 192852 (Attorney Docket No. 020017-000320US), filed Jul. 29, 2005, which was a continuation-in-part of U.S. application Ser. No. 09 / 708,186 (Attorney Docket No. 020017-000310US), filed Nov. 7, 2000 (now U.S. Pat. No. 6,959,708), which claimed the benefit of U.S. Provisional Patent Application Nos. 60 / 164,125, filed on Nov. 8, 1999 and 60 / 185,495, filed on Feb. 28, 2000, each of which is incorporated by reference herein.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] The present invention relates to drug delivery. More particularly, the present invention relates to methods and apparatus for delivering agents that cause vasoconstriction to mucosal and other tissue surfaces in the presence of capnic gases, particularly for the treatment of migraine headaches. [0004] Drug delivery to mucosal surfaces, such as the mucosa of the nose, is well known...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K33/00A61K31/48A61K31/4184
CPCA61H33/14A61H2033/145A61K33/00A61K45/06A61M15/0065A61M15/009A61M15/0083A61M2202/0225A61M2202/064A61M37/00A61M15/0041A61M2202/0007A61P43/00
Inventor RASOR, JULIA S.RASOR, NED S.PEREIRA, GERARD F.
Owner CAPNIA INC
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