Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Process for producing granules containing branched amino acids

a technology of branched amino acids and granules, which is applied in the field of producing granules containing branched amino acids, can solve the problems of large preparation volume, difficult swallowing during administration, and large space in the mouth, and achieves the effects of easy swallowing and elimination, and easy swallowing

Inactive Publication Date: 2005-01-06
AJINOMOTO CO INC
View PDF8 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0026] For the production of the granule preparation of the present invention, flavoring agents such as sweetening agents (e.g., saccharin sodium, aspartame etc.), odor improving agents (e.g., menthol, lemon flavor etc.), and the like, which are of the kinds generally employed, can be added.
[0027] The granule containing the aforementioned three kinds of amino acid particles in the pharmaceutical granule preparation of the present invention can be produced using any instrument

Problems solved by technology

However, when this requirement is to be met by reducing the size of starting material amino acid particles as in the case of conventional solid preparations, the volume thereof in one dose increases, which in turn makes the preparation bulky and difficult to swallow during administration.
In the case of the aforementioned three kinds of branched chain amino acid particles, a single dose of the branched chain amino acids is about 4-5 g. Therefore, when a granule preparation is produced by pulverizing them to not more than 50 μm, its volume becomes about 8-10 mL and takes up much space in the mouth, making it extremely difficult to swallow.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0036] Three kinds of branched chain amino acids (weight ratio, leucine:isoleucine:valine=2:1:1.2), 2.3 kg, pulverized in advance was mixed to give a branched chain amino acid mixture having a median size of 22 μm.

[0037] Thereto was added a binding solution having a composition shown in Table 1, and the mixture was granulated in a high-shear granulator (high speed mixer FS-10, manufactured by Fukae Powtec Co., Ltd.; agitator 300 rpm, chopper 3600 rpm, 15 min). The obtained wet granulated product was dried in a flow coater FLO-5 (manufactured by Freund Corporation) at a charge air temperature of 80° C. to give a dry granule. The granules had a specific volume of 1.88 mL / g.

TABLE 1componentamountpovidone 23.2 gpolyvinyl alcohol 19.1 gtartaric acid 23.1 gsaccharin sodium 9.9 gpurified water  750 gtotal825.4 g

example 2

[0038] Three kinds of branched chain amino acids (weight ratio, leucine:isoleucine:valine=2:1:1.2, 2.3 kg) pulverized in advance in the same manner as in Example 1 was mixed to give a branched chain amino acid mixture having a median size of 22 μm.

[0039] Thereto was added a binding solution having a composition shown in Table 2, and the mixture was granulated in a high-shear granulator (high speed mixer FS-10, manufactured by Fukae Powtec Co., Ltd.; agitator 300 rpm, chopper 3600 rpm, 15 min). The obtained wet granulated product was dried in a flow coater FLO-5 (manufactured by Freund Corporation) at a charge air temperature of 80° C. to give a dry granule. The granules had a specific volume of 1.93 mL / g.

TABLE 2componentamountpovidone 23.2 gpolyvinyl alcohol 19.1 gcitric acid 23.2 gsaccharin sodium 9.9 gpurified water  850 gtotal925.4 g

example 3

[0042] Three kinds of branched chain amino acids (weight ratio, leucine:isoleucine:valine=2:1:1.2, 2.3 kg) was mixed and ground in a pin mill (sample mill manufactured by NARA MACHINERY CO., LTD.) using a 3 mmφ screen to give a branched chain amino acid ground mixture having a median size of 219 μm.

[0043] Thereto was added a binding solution having a composition shown in Table 4, and the mixture was granulated in a high-shear granulator (high speed mixer FS-10, manufactured by Fukae Powtec Co., Ltd.; agitator 300 rpm, chopper 3600 rpm, 15 min). The obtained wet granulated product was dried in a flow coater FLO-5 (manufactured by Freund Corporation) to give dry granules. The granules had a specific volume of 1.59 mL / g.

TABLE 4componentamountpovidone 23.2 gpolyvinyl alcohol 19.1 gtartaric acid 11.6 gsaccharin sodium 9.9 gpurified water330.0 gtotal393.8 g

Industrial Applicability

[0044] The branched chain amino acid-containing granule produced by the present invention has a smaller sp...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Specific volumeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The problem of the present invention is to provide pharmaceutical granules containing, as active amino acid ingredients, three kinds of branched chain amino acids of isoleucine, leucine and valine, which has a smaller specific volume than conventional products, and a production method thereof. As a result of intensive studies, granules containing, as active amino acid ingredients, three kinds of branched chain amino acids of isoleucine, leucine and valine and a production method thereof have been provided, which are characterized by adding an acid to a particle mixture of three kinds of branched chain amino acids of isoleucine, leucine and valine and granulating the mixture, which has solved the above-mentioned problem.

Description

CONTINUING APPLICATION DATA [0001] The present application is a continuation of International application No. PCT / JP03 / 00578, filed Jan. 23, 2003, which claims benefit to Japanese patent application No. 15003 / 2002 filed Jan. 24, 2002, which is incorporated herein by reference.TECHNICAL FIELD [0002] The present invention relates to pharmaceutical granules containing three kinds of branched chain amino acids of isoleucine, leucine and valine as active amino acid ingredients, and a production method thereof. BACKGROUND ART [0003] A pharmaceutical preparation containing three kinds of branched chain amino acids of isoleucine, leucine and valine as active ingredients is an effective therapeutic agent for liver diseases. These three kinds of branched chain amino acids have a strong bitter taste and unique amino acid smell and require large amounts for one dose. For production of a preparation, therefore, the problems of reduction of bitter taste and smell, a small-volume of a dose and the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/00A61K9/16A61J3/06A61K31/198A61K47/04A61K47/12A61P1/16
CPCA61K9/0095A61K31/198A61K9/1635A61K9/1617A61P1/16A61K9/16
Inventor SAKAI, HIDETOSHIIDA, MITSUYASUMAKINO, CHISATOKAWANO, TOMOAKIYABUKI, AKIRA
Owner AJINOMOTO CO INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com