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Microbulb ultrasonic contrast medium and its connection method with antibody, targeting gene and gene

A technology of targeting groups and contrast agents, which is applied in the field of medical imaging, can solve problems such as steric hindrance, achieve efficient connection and solve steric hindrance problems

Inactive Publication Date: 2010-05-12
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a class of ultrasonic microbubble contrast agents that can be efficiently connected to antibodies, targeting groups, and genes, which solves the problem of the efficiency of microbubbles when they are connected to drugs such as antibodies, targeting groups, and genes, and easily causes The problem of steric hindrance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Microbubble Membrane Solution Formulation with Polyethylene Glycol Adhesive Tethers:

[0032] Polyethylene glycol 800 (linking polymer) 12.5g (50%)

[0033] Polyethylene glycol 3000 (film material) 0.25g (1%)

[0034] Tween 80 (emulsifier) ​​0.25g(1%)

[0035] Sucrose (film stabilizer) 12g (48%)

[0036] Normal saline (buffer) balance

Embodiment 2

[0038] Microbubble membrane solution formulation with polyethylene glycol linker:

[0039] Polyethylene glycol 800 (linking polymer) 0.5g (1%)

[0040] Polyethylene glycol 3000 (film material) 17g (34%)

[0041] Tween 80 (emulsifier) ​​7.5g (15%)

[0042] Lauric acid (membrane stabilizer) 25g (50%)

[0043] Phosphate buffer solution (buffer) at pH 7.0 balance

Embodiment 3

[0045] Microbubble membrane solution formulation with polyethylene glycol linker:

[0046] Polyethylene glycol 600 (linking polymer) 0.4g (1%)

[0047] Polyethylene glycol 800 (linking polymer) 1.6g (4%)

[0048] Polyethylene glycol 1500 (film material) 24g (60%)

[0049] span60 (film material) 12g(30%)

[0050] Tween 80 (emulsifier) ​​1.6g (4%)

[0051] Glucose (membrane stabilizer) 0.4g (1%)

[0052] Phosphate buffer solution (buffer) of pH7.01 balance

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PUM

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Abstract

The microbubble ultrasonic contrast medium consists of connecting polymer 1-50 wt%, other filming material 1-90 wt%, film stabilizer 1-50 wt% and emulsifier 1-15 wt%. The microbubble contrast medium is connected to antibody, targeting group or gene with the low smelting point and long straight chain biocompatible polymer or low smelting point biocompatible polymer with small side chain group and no produced steric hindrance as one component of the microbubble film. At the temperature without inactivation of antibody, targeting group or gene, the prepared microbubble is mixed with antibody, gene or other medicine for combination effectively. The present invention solves the problem of connecting microbubble contrast medium with antibody, targeting group, gene and other medicine simply without steric hindrance.

Description

technical field [0001] The invention belongs to the technical field of medical imaging, and relates to a drug-carrying microbubble ultrasound contrast agent used in ultrasonic diagnosis and treatment, in particular to a type of microbubble ultrasound contrast agent that can effectively connect antibodies, targeting groups, genes and other drugs. The invention also relates to a method for linking the microbubble ultrasound contrast agent with antibodies, targeting groups and genes. Background technique [0002] Ultrasound contrast agents are a class of diagnostic agents that can significantly enhance medical ultrasound detection signals. In terms of human microvascular and tissue perfusion detection and imaging, the use of ultrasound contrast agents for ultrasonic detection has good imaging effects, real-time, easy operation, no ion radiation, Non-destructive, wide applicability and other advantages, so it has been more and more used in medical clinical testing. Ultrasound i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22
Inventor 杜永峰姚秉华高彩霞
Owner XIAN UNIV OF TECH
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