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Slow released capsule of tobramycin and bletilla tuber glue for animal and birds

A technology of tobramycin and sustained-release capsules, which is applied in the field of preparation of veterinary drug tobramycin bletilla striata gum bioadhesive sustained-release capsules and its preparation, which can solve the problem of unsatisfactory adhesion and drug release performance and the threat of dangerous diseases , unsatisfactory safety and other issues, to achieve the effect of improving drug treatment effect, good therapeutic effect, and improving bioavailability

Inactive Publication Date: 2007-06-27
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main problems of animal products in my country are: first, the threat of dangerous diseases; second, drug residues
Natural materials are non-toxic and have good biocompatibility, but their adhesion and drug release properties are not ideal; synthetic materials have better adhesion and drug release properties, but are expensive and unsatisfactory in safety
Therefore, currently few bioadhesive materials fully meet the requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Preparation of tobramycin bletilla striata gum bioadhesive sustained-release capsules

[0014] a. Preparation of Bletilla striata glue: 5kg of Bletilla striata, crushed, added 40L of distilled water, heated in a water bath at 60°C to keep warm and impregnated, stirred, the extract was filtered through four layers of gauze, the dregs were added with distilled water, repeatedly impregnated, the filtrate was combined several times, concentrated, Add 95% ethanol to make the alcohol content reach 70%, precipitate a large amount of white flocculent precipitate, let it stand overnight, filter the next day, recover the ethanol, collect the precipitate, wash with ethanol three times, evaporate the ethanol, and dry it at about 80°C , weighed, and pulverized to obtain 1.1kg of Bletilla striata gum; Bletilla striata gum: its properties are yellow dry powder, tasteless and odorless, insoluble in ethanol, soluble in water, and in the form of a thick colloid. α-Naphthol con...

Embodiment 2

[0016] Example 2: The prepared Tobramycin Bletilla striata glue bioadhesive sustained-release capsules were used to treat various infections of livestock and poultry caused by Gram-negative bacilli. The way of administration is mixing or drinking water, poultry 0.004g / kg body weight, livestock 0.009g / kg body weight, twice a day, 3-5 days as a course of treatment.

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PUM

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Abstract

The present invention belongs to the field of veterinary medicine technology, and is especially slow released veterinary medicine capsule prepared with tobramycin and bletilla tuber as material. The preparation process includes the following steps: water extracting and alcohol precipitation to extract bletilla tuber glue; mixing tobramycin and bletilla tuber in the ratio of 1 to 3 and 10 % concentration alcohol solution of PVP as adhesive; making pellet of 20 meshes and encapsulating. The slow released veterinary medicine capsule has long medicine retaining time in the disease focus, high local medicine concentration, excellent bioadhesion and obvious medicine slow releasing characteristic.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, in particular to the preparation of veterinary drug tobramycin and bletilla striata glue bioadhesive sustained-release capsules by using tobramycin and bletilla striata as raw materials and a preparation method thereof. Background technique [0002] As my country's animal husbandry is developing towards intensive and intensive direction, and the scale of animal husbandry continues to expand, ensuring the quality and safety of animal husbandry products has become an important issue that we need to solve. At present, the main problems of animal products in my country are: first, the threat of dangerous diseases; second, drug residues. Among them, drug residues in animal foods have endangered people's health. Therefore, the rational use of animal veterinary drugs and health products to control diseases and drug residues in the process of animal husbandry is an important problem that needs ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/52A61K47/36A61K31/7036A61P31/04
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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