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Process for preparing functional high molecule composite micro ball with quick magnetic field responsiveness

A technology of functional polymers and composite microspheres, which is applied in the field of preparation of functional polymer composite microspheres, can solve the problems of long time consumption, insignificant improvement, and difficult control of the reaction process, and achieve the effect of increasing the coating amount

Active Publication Date: 2007-04-11
SHANGHAI ALLRUN NANO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of this method are: many reaction steps, long time-consuming, difficult to control the reaction process, in addition, Fe in the prepared magnetic microspheres 3 o 4 The content is 34.7wt%. Although it has been improved to a certain extent compared with the traditional method, the extent of improvement is not significant.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 26.9g FeSO 4 ·7H 2 O and 18.4 g FeCl 3 ·6H 2 O, dissolved in 50ml of deionized water, after the iron salt is completely dissolved, add it into a 250ml three-neck flask, under nitrogen protection, stir at 300rpm, heat up to 70°C, then quickly add 50ml of ammonia water, and add 2g of oleic acid and 3g of The mixture of undecylenic acid was maintained at 70°C for 1 hour, then the bottle was opened, the temperature was raised to 85°C, and the temperature was kept for 60 minutes to evaporate excess ammonia water. When the pH value of the system was 7±1, stop evaporation , cooled to room temperature, and then washed with absolute ethanol and deionized water three times under the action of an external magnetic field to remove excess ammonia salt, oleic acid and undecylenic acid. The washed Fe 3 o 4 The particles were dried in an oven at 80°C for 15 minutes, and finally Fe 3 o 4 The particles are dispersed in n-octane in situ to form a magnetic fluid, and the Fe 3 ...

Embodiment 2

[0021] According to the method described in Example 1, the difference is that the addition of acrylic acid is 0.24g, and other processing methods are the same as the reaction temperature and time.

[0022] The surface carboxylated magnetic composite microspheres Fe prepared in this example 3 o 4 The nanoparticle content can reach 69wt%, the surface carboxyl group density is 0.0587mmol / g, the average particle diameter is 64nm, and has superparamagnetism.

Embodiment 3

[0024] According to the method described in Example 1, the difference is that the addition of acrylic acid is 2.4g, and other processing methods are the same as the reaction temperature and time.

[0025] The surface carboxylated magnetic composite microspheres Fe prepared in this example 3 o 4 The nanoparticle content can reach 69.4wt%, the surface carboxyl group density is 0.251mmol / g, the average particle diameter is 41nm, and has superparamagnetism.

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Abstract

The present invention relates to composite material technology, and is especially preparation process of functional high molecular composite micro ball with quick magnetic field response. The preparation process includes the first coprecipitation to prepare superparamagnetic nanometer Fe3O4 particle with renselin and oleic acid modified surface and in-situ dispersing in n-octane to form oil base magnetic fluid; and the subsequent fine emulsion process to prepare composite superparamagnetic high molecular composite micro ball with carboxylated surface.The composite micro ball of the present invention has magnetic material content up to 78 wt %, average particle size of 41-185 nm and surface carboxy radical density of 0.0587-0.251 mmol / g, and may be applied in cell separation, target medicine and other biomedicine fields.

Description

technical field [0001] The invention relates to a method in the technical field of composite materials, in particular to a method for preparing functional polymer composite microspheres with fast magnetic field responsiveness. Background technique [0002] In recent years, surface-functionalized magnetic polymer composite microspheres have attracted more and more attention because of their special properties and wide range of applications. There are functionalized groups on the surface of functionalized magnetic polymer composite microspheres that can chemically cross-link with biologically active substances. At the same time, because of its strong magnetic field responsiveness, it can be easily and quickly separated under the action of an external magnetic field. Therefore, it has broad application prospects in biomedical fields such as immobilized enzymes, immunoassays, protein purification, targeted drug delivery, and cell separation. [0003] At present, the methods for...

Claims

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Application Information

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IPC IPC(8): C08F2/44C08F12/08C08F12/36C08K9/04H01F1/42C08K3/22
Inventor 贺枰崔陇兰徐宏古宏晨
Owner SHANGHAI ALLRUN NANO SCI & TECH
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