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Pharmaceutical use of sophora alkaloids tanate for preventing and treating skin and mucosa infection

A technology of matrine and tannic acid, which is applied in the field of application of matrine tannic acid in the preparation of drugs for the prevention and treatment of skin and mucous membrane infections, and can solve the problems of unidentified active ingredients, difficult quality control, and useless anti-HPV virus

Inactive Publication Date: 2007-03-28
秦卫华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The above patents and documents have the disadvantages of complex prescriptions, many ingredients, unclear active ingredients, and difficult quality control. They are not used for anti-HPV viruses, and there is no experimental data to prove that they can kill viruses.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of tannin matrine anti-HPV virus effervescent tablets:

[0031] Matrine Tannin 1.00g

[0032] Tartaric acid 0.45 g

[0033] Sodium bicarbonate 0.65 g

[0034] Dextrin 0.02 g

[0035] PEG6000 0.01 g

[0036]Preparation method: Take the tannin matrine and tartaric acid through 80 mesh sieve respectively, make soft material with 95% ethanol, pass through 12 mesh sieve to make wet granules, dry at 50° C., and set aside. Separately take sodium bicarbonate and sterile distilled water to make a soft material, pass through a 12-mesh sieve to make wet granules, dry at 50℃, then mix with the above dry granules, sizing, add appropriate amount of sterilized distilled water, bake for a while, add PEG6000, dextrin . Mix well and compress into tablets.

Embodiment 2

[0038] Preparation of Matrine Tannin Disinfectant:

[0039] Matrine Tannin 10g

[0040] 1,2-Propanediol 15ml

[0041] Tween-80 15ml

[0042] Azone 3ml

[0043] Adjust pH to 5.5 with HCl or NaOH

[0044] Add sterile distilled water to 100ml

Embodiment 3

[0046] Preparation of compound tannin matrine gel:

[0047] Matrine Tannin 10g

[0048] Carbomer 10g

[0049] Glycerin 100g

[0050] Add sterile distilled water to 1000ml

[0051] Preparation method: Take carbomer and sprinkle it into appropriate amount of sterilized distilled water to make it slowly swell, add glycerin and mix thoroughly, add dropwise triethanolamine and stir to form a transparent matrix, and adjust the pH to 6.5-7.5. Take 10 grams of tannin matrine and add it to an appropriate amount of hot sterilized distilled water, dissolve and cool, and then stir it into the gel matrix while adding it, and finally add sterile distilled water to 1000 ml, stir evenly and distribute.

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PUM

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Abstract

The present invention relates to an application of tannic acid and its matrine or their composition in preparationof medicine for preventing and curing mucocutaneous infection, including human papillomavirus infection, pointed condyloma, vaginitis, cervicitis and cervical erosion.

Description

Technical field [0001] The present invention relates to the application of matrine tannin salt or its composition in preparing medicines for preventing skin and mucous membrane infections. Specifically, it relates to the application of tannic acid and its salt formed with matrine and / or its composition for preparing a medicine for treating human and animal skin mucous membrane human papillomavirus infection. Background technique [0002] Bacteria, fungi and viruses in skin and mucous membranes are common and frequently-occurring diseases. At present, antibiotics are often used for treatment, but they often cause drug resistance and make skin and mucous membrane infections lasting for a long time. At the same time, it can treat bacterial, fungal and viral skin and mucous membrane infections. It has not been seen in the market or in the literature. [0003] Condyloma acuminata is a skin and mucous membrane lesion caused by human papillomavirus (HPV). Chinese medicine believes that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61K31/4375A61K9/00A61P17/12A61P15/02A61P15/00A61P31/12A61P31/10A61P31/04
Inventor 秦卫华刘元
Owner 秦卫华
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