Oil-in-water nanometer perilla seed oil emulsion oral liquid and its prepn process
A technique of perilla seed oil and oral emulsion, applied in the fields of medicine, food and health care products, can solve the problems of poor solubility, unstable physical properties and low utilization rate of perilla seed oil, so as to prevent senile dementia, improve the Bioavailability, blood pressure lowering effect
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Embodiment 1
[0043]Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 1.8g of Tween-80, 0.6g of Span-80, and 0.6g of liquid paraffin, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 25°C, then add 0.1g of perilla seed oil directly, Stir well, then slowly add distilled water to it, and manually stir while adding distilled water. At the beginning, the system viscosity is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanometer. Milk, continue to add dropwise and constantly stir, when the system suddenly becomes thinner, what produce now is the stable yellow transparent oil-in-water type perilla seed oil nanoemulsion oral liquid, claiming that its total weight is 10.0g.
Embodiment 2
[0045] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 3.6g of polyoxyethylene hydrogenated castor oil, 0.4g of wheat germ oil, and 0.05g of vitamin E oil, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 24°C. Add it directly, stir until it is completely dissolved, then slowly add distilled water to it, and stir manually while adding distilled water. Water-in-oil type nanoemulsion, continue to drop and constantly stir, when the system suddenly becomes thinner, what produce this moment is the stable colorless transparent oil-in-water type perilla seed oil nanoemulsion oral liquid, and its total weight is called 10.35g.
Embodiment 3
[0047] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 4.5g of polyoxyethylene hydrogenated castor oil and 0.5g of olive oil, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 25°C, add 1.0g of perilla seed oil directly, and stir until completely dissolved , then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the system viscosity is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion. Continue to add dropwise and constantly stir, when the system becomes thinner suddenly, what produces now is the stable colorless transparent oil-in-water type perilla seed oil nanoemulsion oral liquid, claiming that its total weight is 10.0g....
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