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Oil-in-water nanometer perilla seed oil emulsion oral liquid and its prepn process

A technique of perilla seed oil and oral emulsion, applied in the fields of medicine, food and health care products, can solve the problems of poor solubility, unstable physical properties and low utilization rate of perilla seed oil, so as to prevent senile dementia, improve the Bioavailability, blood pressure lowering effect

Inactive Publication Date: 2007-03-21
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, perilla seed oil has poor solubility, unstable physical properties, is volatile, easily rancid, is difficult to preserve, is difficult to disperse in water, and has low utilization rate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043]Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 1.8g of Tween-80, 0.6g of Span-80, and 0.6g of liquid paraffin, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 25°C, then add 0.1g of perilla seed oil directly, Stir well, then slowly add distilled water to it, and manually stir while adding distilled water. At the beginning, the system viscosity is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanometer. Milk, continue to add dropwise and constantly stir, when the system suddenly becomes thinner, what produce now is the stable yellow transparent oil-in-water type perilla seed oil nanoemulsion oral liquid, claiming that its total weight is 10.0g.

Embodiment 2

[0045] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 3.6g of polyoxyethylene hydrogenated castor oil, 0.4g of wheat germ oil, and 0.05g of vitamin E oil, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 24°C. Add it directly, stir until it is completely dissolved, then slowly add distilled water to it, and stir manually while adding distilled water. Water-in-oil type nanoemulsion, continue to drop and constantly stir, when the system suddenly becomes thinner, what produce this moment is the stable colorless transparent oil-in-water type perilla seed oil nanoemulsion oral liquid, and its total weight is called 10.35g.

Embodiment 3

[0047] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 4.5g of polyoxyethylene hydrogenated castor oil and 0.5g of olive oil, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 25°C, add 1.0g of perilla seed oil directly, and stir until completely dissolved , then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the system viscosity is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion. Continue to add dropwise and constantly stir, when the system becomes thinner suddenly, what produces now is the stable colorless transparent oil-in-water type perilla seed oil nanoemulsion oral liquid, claiming that its total weight is 10.0g....

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Abstract

The oil-in-water nanometer perilla seed oil emulsion oral liquid consists of surfactant, oil, perilla seed oil and distilled water. Its preparation process includes the following steps: weighing surfactant with or without co-surfactant; calculating HLB value and selecting oil phase for reaching emulsifying HLB value near that of the surfactant phase; changing the ratio between the surfactant phase and the oil phase regularly; adding perilla seed oil into surfactant through stirring at 20-25 deg.c; adding distilled water slowly to form clear and flowing O / W type nanometer emulsion liquid. The nanometer perilla seed oil emulsion preparing process results in raised stability, raised bioavailability, delayed in vivo metabolism time, reduced supplementary material amount, lowered production process and wide medicine market foreground.

Description

technical field [0001] The invention belongs to the fields of medicine, food and health products, and relates to a medicine preparation and a preparation method thereof, in particular to a transparent and stable oil-in-water perilla seed oil nanoemulsion oral liquid and a preparation method thereof. Background technique [0002] Perilla was first recorded in the earliest medical classic "Shen Nong's Herbal Classic" in the Han Dynasty in my country 2,500 years ago. The book says: "Su Zi tastes sweet and warm, long-term consumption can lighten the body", and it also says: "Su is comfortable and has the power of promoting qi and blood, so it is called Su." Its taste is pungent in nature, and it has the effects of lowering qi and eliminating illness, relieving asthma, and moistening the intestines. It has been recorded in Chinese Pharmacopoeia, but its clinical application only stays at the level of decocting perilla seed in water, lowering Qi and eliminating illness, relieving...

Claims

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Application Information

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IPC IPC(8): A61K36/535A61K9/107A61K47/44A61P3/06A61P9/10A61P11/06A61P1/10A23L1/29A23L33/00
Inventor 欧阳五庆吴旭锦
Owner NORTHWEST A & F UNIV
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