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Medicine for curing cardiovascular disease and its preparation method

A cardiovascular and disease technology, applied in the field of traditional Chinese medicine preparations, can solve the problems of affecting the efficacy of medicines, differences in the decoction rate of active ingredients, and no clear regulations on concentration, and achieve the effects of easy storage and transportation, high effective concentration, and stable quality

Inactive Publication Date: 2007-03-14
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the use of this prescription, it was found that the main problem is that there is no clear regulation on the amount of white wine or rice wine added and the concentration of ethanol. Different patients use different concentrations or different amounts of white wine or rice wine. The active ingredients of medicines are different, so there is a big difference in the decoction rate of the active ingredients of the medicine, which directly affects the curative effect of the medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 4 portions of 200g Trichosanthes and 200g Xiebai respectively, mix the same amount of Trichosanthes and Xiebai, and extract twice with 60% ethanol under reflux, adding ethanol solution 8 times the weight of the medicinal materials each time, for 1 hour each time. Recover the ethanol from the extract until the alcohol content is less than 5%, add 5 times the volume of the extract with water, put it on the D101 macroporous adsorption resin, first elute with 2 times the volume of the resin, and then use 4 times the volume of the resin to elute 10%, 30%, 60%, and 80% ethanol by volume are eluted, and the ethanol is recovered to obtain the ethanol extract (EE) of Trichosanthes xiebai.

[0039] Pharmacodynamic test method:

[0040] experiment material:

[0041] EE (self-made, add distilled water before use to prepare a suspension of appropriate concentration); isoproterenol hydrochloride, Shanghai Hefeng Pharmaceutical Co., Ltd.; sodium lime, Shanghai Fourth Pharmaceuti...

Embodiment 2

[0047] Take 2000g of Trichosanthes and Allium, reflux extraction twice, 1.5 hours each time, add 10 liters of 60% ethanol each time, combine the filtrate, recover the ethanol, add water 4 times the volume of the medicinal solution, and put it into the AB-8 macropore The adsorption resin was first eluted with 0.5 times the amount of water of the resin volume, and then eluted with 60% ethanol 4 times the volume of the resin to obtain 92 g of the ethanol extract of Fructus Albae. Take 40g of the ethanol extract of Trichosanthes and Allium scallops, add 120g of starch, mix well, add 40ml of 95% ethanol to granulate, dry at 60°C, granulate, add 0.5% magnesium stearate of granule weight as lubricant, mix well, Fill the No. 0 capsule to get the medicine capsule of the present invention.

Embodiment 3

[0049]Take 50 g of the ethanol extract powder of Trichosanthes quince and Allium scallions obtained in Example 2, add 120 g of starch, 75 g of microcrystalline cellulose, mix well, add 90% ethanol to granulate, dry, granulate, and add cross-linked carboxymethyl cellulose Plain sodium 25g and appropriate amount of magnesium stearate are mixed, and tabletting obtains pharmaceutical tablet of the present invention.

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PUM

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Abstract

The invention relates to a drug used to treat heart blood vessel disease, and relative production. Wherein, said drug is formed by the alcohol extractives of chavicol and leek, and relative auxiliary materials; and the extraction method of them comprises adding alcohol water solution into chavicol and leek, to be heated, refluxed and extracted; combining the extractive solutions, recycling and concentrating alcohol until the volume percentage of alcohol is lower than 5%; diluting with water, adding porous adsorption resin, washing out foreign material with water, and washing with alcohol water solution, collecting the alcohol elution, concentrating and recycling the alcohol to obtains said alcohol extractives. Compared with present traditional medicine, the invention has high effective density, reduce the oral amount, and remove the inactive component.

Description

technical field [0001] The invention relates to a medicine for treating cardiovascular diseases and belongs to the field of traditional Chinese medicine preparations. Background technique [0002] Gualou Xiebai Baijiu Decoction comes from "Synopsis of the Golden Chamber" written by Zhang Zhongjing, a famous doctor in the Han Dynasty. It has the effects of unblocking yang and dispelling stagnation, promoting qi and eliminating phlegm. It is a representative prescription used in Chinese medicine for treating chest obstruction. It is also one of the basic prescriptions used to treat coronary heart disease, angina pectoris and myocardial infarction for more than ten years. Valuable ancient recipe. [0003] The method of use of this prescription is described as "decocting with an appropriate amount of rice wine and water" in "Prescription Studies" (Edited by Xu Jiqun, the first edition in June 1985, Shanghai: Shanghai Science and Technology Press, page 139). During the use of t...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P9/10
Inventor 高文远张鹏威陈海霞王书军
Owner TIANJIN UNIV
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