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Water free flower red drug administration system and preparing technique

A drug delivery system, non-aqueous technology, applied in the field of traditional Chinese medicine non-aqueous drug delivery system and its preparation, can solve the problems of difficult drug effect, slow drug release, difficult drug dissolution and purpose, etc., to achieve non-degradable, stable products, The effect of improving adherence

Inactive Publication Date: 2007-03-14
张勇 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above-mentioned shortcomings, there have been three new preparation patents about Huahong compound medicine: "Huahong pill and its preparation method" (patent application No. 03124509.9); "Huahong dispersible tablet and its preparation method" (Patent No. CN 200410023398.7); "Huahong soft capsule and its preparation method" (Application No. 200410004558.3), respectively described the preparation method of the new dosage form of Huahong in the three patents, the extraction process of the medicinal material has not been significantly changed, and still retains a part of the original powder of the medicinal material for use as medicine, (preparation For details of the process and prescription, please refer to the Compilation of Standards of Chinese Patent Medicine of the State Drug Administration——The local standard of Chinese patent medicine has risen to the national standard part "Gynecology Subvolume"). It is made into dispersible tablets or pills, and it is still a solid preparation, and there is also drug release. Slower phenomenon, the drug effect is also difficult to exert; the diluent used in the Huahong soft capsule patent is vegetable oil, the drug particles are wrapped in oil, and it is difficult to release quickly in the gastrointestinal tract, so it is difficult for the dosage forms described in these patents to achieve improved drug dissolution and purpose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Contents recipe:

[0032] Ingredient: weight per capsule (mg)

[0033] A little red fine powder 128

[0034] Extract 145

[0035] PEG400 250

[0036] Tween 80 15

[0037] beeswax 10

[0038] Bonus non-aqueous drug delivery system:

[0039] Take 128g of a little red, crush it into a fine powder, add the remaining a little red and other six traditional Chinese medicines such as Hedyotis diffusa, Peach Blossom, White-backed Tong, Xingming, Spatholobus, Myrtle, etc., add water and boil twice, the first time 2 hours, 1.5 hours for the second time, combine the decoction, filter, concentrate the filtrate to an extract with a relative density of 1.18-1.23 (80°C), add ethanol to make the alcohol content reach 65%, stir well, and let it stand for 24 hours , filtered, and the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.25-1.30 (80°C), dried for later use. Heat and melt Tween 80 and beeswax into PEG400, dissolve the extract in PEG...

Embodiment 2

[0041] Contents recipe:

[0042] Ingredient: weight per capsule (mg)

[0043] Extract 165

[0044] PEG400 300

[0045] Tween 80 15

[0046] beeswax 10

[0047] Bonus non-aqueous drug delivery system:

[0048] Add a little red, Hedyotis diffusa, Peach Blossom, Hedyotis diffusa, Peach Blossom, Spathiphyllum, Myrtle and other seven Chinese herbal medicines, add water and decoct twice, the first time for 2 hours, the second time for 1.5 hours, combine Decoction, filter, concentrate the filtrate to the extract with a relative density of 1.18-1.23 (80°C), add ethanol to make the alcohol content reach 65%, stir well, let stand for 24 hours, filter, recover the ethanol from the filtrate under reduced pressure and Concentrate to a relative density of 1.25-1.30 (80°C), dry and use. Add Tween 80 and beeswax to PEG400 after heating and melting, dissolve the extract in PEG400, pass through a colloid mill and mix evenly.

Embodiment 3

[0050] Ingredient: weight per capsule (mg)

[0051] A little red fine powder 128

[0052] Extract 145

[0053] PEG400 270

[0054] PEG6000 9

[0055] Tween 80 30

[0056] beeswax 18

[0057] The process is as follows:

[0058]Take 128g of a little red, crush it into fine powder, add the remaining a little red and other Chinese herbal medicines such as Hedyotis diffusa, Peach Blossom, White-backed Tong, Xingming, Spatholobus, Myrtle, etc., and decoct it twice, the first time 2 hours, 1.5 hours for the second time, combine the decoction, filter, concentrate the filtrate to an extract with a relative density of 1.18-1.23 (80°C), add ethanol to make the alcohol content reach 65%, stir well, and let it stand for 24 hours , filtered, and the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.25-1.30 (80°C), and dried for later use. Add PEG6000, Tween 80 and beeswax to PEG400 after heating and melting, dissolve the extract in PEG400, and d...

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PUM

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Abstract

The invention discloses a non-water administration system for tasselblower, which comprises tasselblower fines, oldenlandia, Urena lobata Linn., Mallotus, Herba thlaspis, spatholobus stem, Rhodomyrtus tomentosa and other medicinal findings including at least one of polyethylene glycol or ethylene glycol monoethyl ether.

Description

technical field [0001] The invention relates to a new drug delivery system for traditional Chinese medicine and a preparation method thereof, in particular to a non-aqueous drug delivery system for traditional Chinese medicine and a preparation method thereof. Background technique [0002] Huahong Tablets and Huahong Capsules are products of Guangxi Huahong Pharmaceutical Co., Ltd. It is a compound preparation composed of seven flavors of traditional Chinese medicines such as Yidianhong, Hedyotis diffusa, Peach Blossom, Baibeitong, Xingming, Milletah, and Myrtle. The effect of clearing away heat and promoting dampness, dispelling blood stasis and relieving pain is suitable for women with damp-heat type who have vaginal discharge, less menstrual flow or dysmenorrhea. According to the retail market monitoring data of SFDA Southern Economic Research Institute, Huahong tablets accounted for 9% of the retail market share of similar products in 2003, ranking fourth, and accounted ...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/08A61K9/10A61K9/48A61P15/00
Inventor 张勇陆兔林
Owner 张勇
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