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Ciclopirox olamine crystal and method for preparing the same

A technology of ciclopirox olamine and crystals, which is applied in the field of ciclopirox olamine crystals and its preparation, to achieve the effect of not being easy to decompose and change color

Active Publication Date: 2007-02-07
LIVZON GROUP CHANGZHOU KONY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Published reports on research on aciclopirox oxamine crystals and their preparation methods in existing literature

Method used

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  • Ciclopirox olamine crystal and method for preparing the same
  • Ciclopirox olamine crystal and method for preparing the same
  • Ciclopirox olamine crystal and method for preparing the same

Examples

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Embodiment 1

[0051] Example 1: Put 10 g of ciclopirox and 60 mL of ethyl acetate into a reaction flask at room temperature, add 4 g of ethanolamine with stirring, continue stirring for 3 hours, filter, and dry under vacuum at 60° C. to obtain 12 g of ciclopirox amine crystals.

Embodiment 2

[0052] Example 2: Put 10 g of ciclopirox and 250 mL of ethyl acetate into a reaction flask, raise the temperature to 70° C., and completely dissolve the solids. Add 4 g of ethanolamine under stirring, stop the stirring, cool to 0°C and let stand for 3 hours, filter, and dry under vacuum at 60°C to obtain ciclopirox olamine crystal form 12.3g.

Embodiment 3

[0053] Example 3: Put 10 g of ciclopirox and 70 mL of acetonitrile into a reaction flask at room temperature, stir and add 4.5 g of ethanolamine, continue stirring for 3 hours, filter, and dry under vacuum at 60° C. to obtain 11.7 g of ciclopirox amine crystals.

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Abstract

The invention discloses a cycloronesketamine crystal and preparing method, which comprises the following steps: 1) dissolving cyclorones and ethanolamine in the solvent or dissolving cycloronesketamine in the solvent with organic solvent and or water; 2) crystallizing the solvent in the step 1) to obtain the product.

Description

technical field [0001] The invention relates to an antifungal drug ciclopirox olamine, in particular to ciclopirox olamine crystals and a preparation method thereof. Background technique [0002] There are two or more molecular arrangements in the solid state of a compound, which are called polymorphs. When referring to a specific crystalline form, it is called a crystal form or crystalline form. Different crystal forms have different lattice energies, and therefore have different properties such as melting point, solubility, dissolution rate, density, hardness, etc., which affect the stability, bioavailability and efficacy of drugs. Understanding the polymorphism and properties of drugs will help to: ensure the equivalence of each batch of produced drugs; ensure the stability and efficacy of drugs; improve the production process of drugs (including raw materials and preparations), etc. For details, please refer to: G.M. Wall, Pharm Manuf. 3 , 33 (1986); J.K. Haleblian an...

Claims

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Application Information

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IPC IPC(8): C07D213/64
Inventor 张建军马立新潘新康
Owner LIVZON GROUP CHANGZHOU KONY PHARMA
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