Probiotic double layer embed microcapsule process

Abstract

The invention discloses a probiotics double-embedded microcapsule technology. The acid-proof double-embedded enteric-coated microcapsule is prepared with 75 % probiotics enriched solution, 15 % milk protein, 10 % capsule-core findings and enteric solubility colloid comprising 12-20 % converted starch, 4-8 % acacia gum, 6-10 % carbowax, 4-8 % sodium alginate, 3-5 % chitose and 60 % common salt with concentration of 0.9 % by fluidized spray-on process. The products by this double-embedded microcapsule technology can resist acid stomach and bile acid and is shelf stable, and can immediately dissolve and release after reaching small intestine and can colonize on adsorption intestinal canal mucous membrane, and the process is much easier and the cost is much lower.

Description

technical field [0001] The invention relates to a probiotic double-layer embedding microcapsule process. Background technique [0002] At present, there are endless probiotic products on the market, but most probiotic products are probiotic products without embedding treatment, such as yogurt, probiotic oral liquid or nutrient solution, freeze-dried bacteria powder, etc., due to gastric acid, bile, etc. Acid has a bactericidal effect, and these probiotics will be inactivated after entering the human body, and cannot exert their ideal curative effect, and they are not durable. There are several embedding technologies for probiotic products in the prior art, one of which is giant-encapsulated probiotics, which is wrapped in hard capsules, which can protect lactic acid bacteria from passing through the stomach, but hard capsules are not easy to dissolve and not Long-term storage; there is also a microcapsule-embedded probiotic product, this microcap...

AI Technical Summary

Problems solved by technology

[0002] At present, there are endless probiotic products on the market, but most probiotic products are probiotic products without embedding treatment, such as yogurt, probiotic oral liquid or nutrient solution, freeze-dried bacteria powder, etc., due to gastric acid, bile, etc. Acid has a bactericidal effect, and these probiotics will be inactivated after entering the human body, and cannot exert their ideal curative effect, and are not durable

There are several embedding technologies for probiotic products in the prior art, one of which is giant-encapsulated probiotics, which is wrapped in hard capsules, which can protect lactic acid bacteria from passing through the stomach, but hard capsules are not easy to dissolve and not Long-term storage; there is also a microcapsule-embedded probiotic product, this microcapsule-embedded type is durable and resistant to gastric acid, but its thermal stability is not good, and its water activity has a great influence on it. At the same time, the gel is not easy to dissolve. It takes about 4-6 hours to dissolve and release in the intestinal tract; CNO1107518.X discloses an acid-resistant enteric-coated microcapsule of active bifidobacteria, and its composite enteric-coated materials are bleached shellac and carboxymethylcellulose magnesium stearate ; or cellulose acetate phthalate, diethyl phthalate, Span 80, stearic acid, etc., the preparation method is to spray and granulate the freeze-dried bacteria in a coating pan, and then use the bacteria powder The microparticles are the capsule core, and the compound enteric-coating material is used as the capsule coating solution, which is prepared by fluidized spraying method; the dosage ratio of the capsule core substance and the capsule coating solution is 2~3:1~1.5 (weight / volume)