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Method for preparing freeze-dry powder and injection preparation of Kudiezi

The technology for freeze-dried powder injection and Kudiezi is applied in the field of preparation of Kudiezi freeze-dried powder for injection, which can solve the problems of polluted raw materials, many impurity components, and low content of active components in purified powder powder, and achieves high content of effective components and low impurities. The effect of few ingredients and easy storage

Inactive Publication Date: 2006-12-06
沈阳斯佳科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a preparation method of Kudiezi freeze-dried powder injection, the purpose is to solve the problem of low active ingredient content and many impurity components in the purified powder; another purpose is to solve the problem of inconvenient storage and use, Easy to contaminate raw materials in the production process, unstable traditional Chinese medicine injections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] The preparation method of Kudiezi freeze-dried powder injection of the present invention is as follows:

[0107] Get 10,000 g of the medicinal material of Pombidium chinensis, crush it through a 20-mesh sieve, add 10 times the amount of 65% ethanol to soak for 12 hours, filter, and add 65% ethanol to the dregs for ultrasonic extraction (power 100W, temperature room temperature) twice. 10 times the amount each time, and the extraction time is 20 minutes each time. Combine the extract and soaked filtrate, filter, recover the ethanol from the filtrate until it has no alcohol smell, filter the water, concentrate to contain 4g of medicinal material per ml, and put it on a polyamide column for purification. First eluted with water until the eluent was colorless, then carried out gradient elution with 4 times column volume 60% and 70% ethanol respectively, discarded the distilled water eluate, collected 60% and 70% ethanol eluate, combined and recovered Ethanol until alcohol-...

Embodiment 2

[0109] Get 10,000 g of the medicinal material of the clampophyllum, crush it through a 20-mesh sieve, add 15 times the amount of 65% ethanol to soak for 24 hours, filter, add 65% ethanol to the dregs for ultrasonic extraction (power 100W, temperature room temperature) twice, and the amount of solvent per 10 times the amount each time, and the extraction time is 20 minutes each time. Combine the extract and soaked filtrate, filter, recover the ethanol from the filtrate until it has no alcohol smell, filter the water, concentrate to contain 4g of medicinal material per ml, and put it on a polyamide column for purification. First eluted with water until the eluent was colorless, then carried out gradient elution with 4 times column volume 60% and 70% ethanol respectively, discarded the distilled water eluate, collected 60% and 70% ethanol eluate, combined and recovered Ethanol until alcohol-free, and dried at 55°C to obtain the purified powder of A. spp. Dissolve the purified ve...

Embodiment 3

[0111] Get 10,000 g of the medicinal material of the clambrachium, crush it through a 20-mesh sieve, add 13 times the amount of 65% ethanol to soak for 15 hours, filter, add 65% ethanol to the dregs for ultrasonic extraction (power 100W, temperature room temperature) twice, and the amount of solvent per 10 times the amount each time, and the extraction time is 20 minutes each time. Combine the extract and soaked filtrate, filter, recover the ethanol from the filtrate until it has no alcohol smell, filter the water, concentrate to contain 4g of medicinal material per ml, and put it on a polyamide column for purification. First eluted with water until the eluent was colorless, then carried out gradient elution with 4 times column volume 60% and 70% ethanol respectively, discarded the distilled water eluate, collected 60% and 70% ethanol eluate, combined and recovered Ethanol until alcohol-free, and dried at 65°C to obtain the purified powder of Kusheria clamosa; dissolve 140 g o...

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PUM

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Abstract

A process for preparing the freeze-dried powder injection of sowthistleleaf ixeris includes such steps as breaking the irexis sonchifolia, immersing in alcohol, filtering, ultrasonic extracting, collecting the immersing liquid and liquid extract, filtering, recovering alcohol, concentrating, purifying with polyamide column, removing eluting distilled water, merging, baking, preparing mannitol solution, dissolving said purified powder in the water for injection, ultrafiltering, mixing it with said mannitol solution, regulating pH=5.5-7.2, adding the water for injection, filtering, pouring in containers and freeze-drying.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a preparation method of Kudiezi freeze-dried powder injection. Background technique: [0002] Kudiezi, also known as Mantianxing, is recorded in the "Dictionary of Chinese Medicine" that the function of Kudiezi is to clear away heat and detoxify, drain pus, and relieve pain. It can treat appendicitis, enteritis, dysentery, various suppurative inflammations, vomiting blood, epistaxis, headache, toothache, chest and abdominal pain, yellow water sores, hemorrhoids, etc. For example, to treat appendicitis, you can use five qian of bitter root, one or two of coix, and two qian of aconite. Decoct it in water and take it twice a day; if treating yellow water sores, you can grind it into powder and apply with sesame oil; if you treat hemorrhoids, you can chop it up and decoct it for fumigation. Modern research has found that Kudiezi has heat-clearing a...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K9/19A61P31/12A61P9/00
Inventor 王光李莉马红萍
Owner 沈阳斯佳科技发展有限公司
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