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Preparing process of calcium-adding hydrolyzed collagen preparation and its product and application

A technology for hydrolyzed collagen and preparations, which is applied in the field of preparation of hydrolyzed collagen plus calcium preparations, and can solve problems such as poor adhesion and low absorption rate of calcium products

Inactive Publication Date: 2006-11-08
WUXI RUINIAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing calcium supplement products generally make calcium compounds into calcium-containing preparations for consumption, and sometimes they need to be taken with vitamin D to increase calcium absorption. The absorption rate of these calcium products is generally low, and the supplemented calcium is in the bone. The adhesion on the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1) Take 9 kg of gelatin and 1 kg of citric acid and mix them into the reactor, then add 56 kg of water to the reactor at room temperature and stir until the solution concentration is 15%, heat to 60°C, keep for 30 minutes, and then heat to 90°C ℃, keep warm for 4 hours to make a hydrolyzed collagen solution; then slowly add 10% sodium hydroxide solution to adjust the pH value to 5.8-6.0;

[0022] 2) filtering the above hydrolyzed collagen solution;

[0023] 3) spray-drying the hydrolyzed collagen solution in step 2) to make hydrolyzed collagen powder;

[0024] 4) Take 5 kg of the above-mentioned hydrolyzed collagen powder, 4.95 kg of anhydrous calcium lactate, 30 grams of aspartame, 20 grams of fresh milk essence and 10 grams of popcorn essence according to the weight ratio and fully mix;

[0025] 5) Granulating the mixed powder in step 4) to make granules.

[0026] The granules are prepared by the following method: 1) Add the mixed powder into the granulation device ...

Embodiment 2

[0028] 1) Take 10 kg of gelatin and 1 kg of citric acid and mix them into the reactor, then add 13.4 kg of water to the reactor at room temperature and stir until the solution concentration is 45%, heat to 60°C, keep for 30 minutes, and then heat to 90°C ℃, keep warm for 4 hours to make a hydrolyzed collagen solution; then slowly add 10% sodium hydroxide solution to adjust the pH value to 5.8-6.0;

[0029] 2) filtering the above hydrolyzed collagen solution;

[0030] 3) spray-drying the hydrolyzed collagen solution in step 2) to make hydrolyzed collagen powder;

[0031] 4) Take 7 kg of the above-mentioned hydrolyzed collagen powder, 2.95 kg of anhydrous calcium lactate, 50 grams of aspartame, 10 grams of fresh milk essence and 20 grams of popcorn essence according to the weight ratio and fully mix;

[0032] 5) The step 4) mixed powder is granulated and packed into capsules to make capsules.

Embodiment 3

[0034] The first 4 steps are the same as those in Example 2 or 3, step 5) After the mixed powder is granulated, it is pressed into tablets to make tablets.

[0035] In addition, the above-mentioned hydrolysis step can adopt alkaline hydrolysis or other hydrolysis methods, and the resulting hydrolyzed collagen solution can also be directly spray-dried without filtering to make powder.

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Abstract

The preparation process of calcium-adding hydrolyzed collagen preparation includes the following steps: hydrolysis comprising mixing gelatin and citric acid in the weight ratio of 9-10 to 1, mixing with water in a reactor and heating to form hydrolyzed collagen solution; spray drying to prepare hydrolyzed collagen powder; and pelletizing after mixing hydrolyzed collagen powder with anhydrous calcium lactate, aspartame, fresh milk essence and pop corn essence. The present invention also relates to the prepared calcium-adding hydrolyzed collagen preparation and its application.

Description

technical field [0001] The invention relates to a method for preparing a hydrolyzed collagen plus calcium preparation, and the product and application thereof. Background technique [0002] Osteoporosis is a worldwide health problem that has attracted increasing attention. At present, there are 200 million people in the world suffering from osteoporosis, and its incidence rate has jumped to the seventh place among common diseases and frequently-occurring diseases. The latest research shows that osteoporosis, which has always been considered as a disease unique to the elderly in our country, actually existed in childhood. At present, there is no safe and effective radical cure in medicine to help the loose bones return to their original state, so correct understanding and early prevention are particularly important. [0003] The composition of human bone includes inorganic and organic components mainly composed of calcium and phosphorus. The organic components are mainly co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61K9/16A61K9/20A61K9/48A61K31/191A61P19/10
Inventor 王福才
Owner WUXI RUINIAN IND
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