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Plant volatile oil having broad spectrum antibiotic activity, its prepn. method and usage

A technology of plant volatile oil and antibacterial activity, applied in the field of medicine, can solve the problems of no antibacterial activity, extraction and preparation methods, research literature and patents for medical use

Inactive Publication Date: 2006-09-20
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been patent reports on the anti-inflammatory, antipyretic, analgesic activity and medical use of the volatile oil of the solidago plant, but so far, there is no research literature on the antibacterial activity, extraction and preparation methods, and medical use of the volatile oil of the solidago plant. and patents

Method used

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  • Plant volatile oil having broad spectrum antibiotic activity, its prepn. method and usage
  • Plant volatile oil having broad spectrum antibiotic activity, its prepn. method and usage
  • Plant volatile oil having broad spectrum antibiotic activity, its prepn. method and usage

Examples

Experimental program
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Effect test

Embodiment 1

[0113] Embodiment 1 Preparation of Solidago canadensis volatile oil

[0114] Plant material: The aerial parts of Solidago canadensis collected at Shanghai Jiangwan Airport in September 2004.

[0115] Plant volatile oil extraction: freshly collected aerial part of Solidago canadensis chopped up, take 1Kg, put it in a 5000mL round bottom flask, add 1000mL of water, heat on direct fire for 8 hours, condense and collect plant volatile oil. The collected plant volatile oil oil-water mixture was stored in a refrigerator at 4°C overnight, and the plant volatile oil was separated with a separatory funnel the next day. Get 10mL of the essential oil of Solidago canadensis.

[0116] Component analysis: The obtained plant volatile oil was analyzed by GC-MS, and 28 components were separated and identified, among which four main active components were germanene D(36), 2-isopropenyl-1-vinyl-p- The relative contents of menth-3-ene (23), bourbonene (26), 2,4-diisopropenyl-1-methyl-1-vinyl-cy...

Embodiment 2

[0117] The preparation of embodiment 2 Solidago canadensis plant volatile oil soft capsule

[0118] Recipe: Canadian solidago plant volatile oil 100mL

[0119] Soft capsule base: gelatin 300g

[0120] Agar 300g

[0121] Take 1000g of ionized water

[0122] Preparation method: put the above-mentioned soft capsule base in a chemical glue tank to make a glue solution, press it into a soft capsule with an RJNJ22 soft capsule machine, control the weight of each pill to 0.5g, and contain 0.1mL of the volatile oil of Solidago canadensis, and obtain Goldenrod Canada Softgels 1000 Capsules.

Embodiment 3

[0123] Embodiment 3 Preparation of Solidago canadensis volatile oil suppository

[0124] Recipe: 100mL of Canadian solidago plant volatile oil, 20g of borneol

[0125] Suppository base: polyoxyethylene stearate 1500g

[0126] Polysorbate 80 75g

[0127] Preparation method: Dissolve borneol with appropriate amount of ethanol, then mix well with solidago canadensis volatile oil and polysorbate 80. In addition, melt polyoxyethylene stearate on a water bath, add the above liquid medicine, stir well, pour it into a suppository mold, take it out after cooling, and make 1000 capsules.

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Abstract

A vegetative volatile oil with broad-spectrum antibacterial activity to Staphylococcus aureus, colibacillus, Bacillus subtitis, etc is prepared from the stem, leaf, flower and fruit of Canadian goldenrod herb. Its 4 active components, it optimal picking-up reason and its preparing process are also disclosed.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the antibacterial activity of solidago canadensis plant volatile oil, its preparation method and its application in medical medicine. technical background [0002] Solidago canadensis L., belonging to Compositae, Solidago canadensis genus, originated in North America, was introduced into my country as a flower in the 1970s, and later became a weed. Along the Hangzhou-Zhejiang-Jiangxi Railway, Ningbo, Taizhou and other places in Zhejiang are widely distributed, causing great ecological disasters. This plant has a medicinal history of more than 100 years in Europe and America, and is used to treat chronic nephritis, cystitis, urinary stones, rheumatism, diabetes and other diseases, but most of them are not extracted. Solidago decurrens Lour. and the traditional Chinese medicinal plant Solidago decurrens Lour. belong to the same family and genus, and their medicinal eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K9/00A61P31/04A61P29/00A61K127/00A61K131/00A61K133/00
Inventor 周铜水张劲松李博陈家宽
Owner FUDAN UNIV
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