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2-deoxidized glucose preparation method

A technology of glucose and glucal sugar, applied in the field of preparation of 2-deoxyglucose, which can solve the problems of high cost, cumbersome reaction process, high toxicity, etc., and achieve the effect of reducing production cost and improving product quality and yield

Inactive Publication Date: 2006-07-12
朱书汉
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Problems solved by technology

[0008] The purpose of the present invention is to solve the shortcomings of high toxicity, complicated reaction process and high cost in the existing preparation method of 2-deoxyglucose. We provide a simple and effective synthetic 2-deoxyglucose with low toxicity, simple reaction process and low cost. Deoxyglucose method

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Embodiment Construction

[0022] Further understand characteristics and effects of the present invention in conjunction with the following examples:

[0023] Add 60kg of D-acetylated glucal sugar and 400L of anhydrous methanol to a 500L reactor, stir to dissolve, slowly add 400g of sodium metal, the pH of the reaction solution is about 10, and control the reaction temperature at 25°C for 12 hours. At the end of the heat preservation, turn on the vacuum pump to distill under reduced pressure, add 400kg of water and 10kg of concentrated sulfuric acid to another 500L reactor, stir the cold brine to cool down, and lower the temperature to 0°C, and the distillation in the 500L reactor is completed to obtain D-glucal. Vacuum pump the material in the 500L reaction kettle into the 500L reaction kettle with sulfuric acid water, stir and keep it warm for 12 hours, control the temperature between -2 and 5°C and finish the heat preservation, add sodium hydroxide for neutralization, and adjust the pH value to about ...

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Abstract

The invention discloses a method for preparing for 2-deoxyglucose. The method uses D-acetylated dextroglucose and the absolute methanol to obtain the D-gluglucosan on the accelerating effect, and then it dose vacuum distillation to evaporate to dryness the methanol, it adds sulfuric acid water solution on the reacting machine to obtain the 2-deoxyglucose by hydrolyzing, it then uses normal method to do re-crystallization to the course product to obtain the 2-deoxyglucose product.

Description

1. Technical field [0001] The invention relates to a preparation method of an organic compound, in particular to a preparation method of 2-deoxyglucose. 2. Background technology [0002] There are many known preparation methods of 2-deoxyglucose at present, and more than ten kinds can be retrieved on American Chemical Abstracts (CA). 2-deoxyglucose (I) is obtained in two steps: [0003] [0004] This synthetic method is simple to operate and relatively low in cost, but it uses the highly toxic heavy metal barium, and the second small step in the first step can be simplified again. [0005] The latest reported synthesis method (PCT Int. Appl., 2004058786, 15 Jul 2004) starts from glucal sugar and obtains 2-deoxyglucose through three steps. [0006] [0007] Although the product obtained by this synthetic method has high purity, it is cumbersome and expensive, and is not suitable for large-scale production and promotion. 3. Contents of the invention [0008] The pur...

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Application Information

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IPC IPC(8): C07H3/08C07H1/00
Inventor 朱书汉张军忍
Owner 朱书汉
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