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Self-assembled luminous current-conducting nano medicine crystal and ultra-thin film and preparation method thereof

A nano drug crystal, conductive nano technology, applied in the direction of nano technology, nano technology, drug combination, etc., can solve the problem of heart, lung and brain hypoxic damage without defense

Active Publication Date: 2006-07-12
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report of self-assembled nano drug crystals that protect against cardiopulmonary and brain hypoxic damage

Method used

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  • Self-assembled luminous current-conducting nano medicine crystal and ultra-thin film and preparation method thereof
  • Self-assembled luminous current-conducting nano medicine crystal and ultra-thin film and preparation method thereof
  • Self-assembled luminous current-conducting nano medicine crystal and ultra-thin film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Prepare the following medicinal solution according to the Pharmacopoeia specification issued by the Ministry of Health of the People's Republic of China:

[0041] 1. Preparation of Ibopridine Hydrochloride Solution 2.5 mg / 5 mL

[0042] 2. Prepare a solution containing 2 mg / 100 ml of isoproterenol hydrochloride

[0043] 3. Preparation of Physiological Salt Buffer Containing 1 mg / 2 mL Superoxide Dismutase

[0044] 4. Preparation of Physiological Salt Buffer Containing 20 mg / 3.3 mL ATP

[0045] 5. Take the solute number of each component within the concentration range of 1:3:3:3, mix evenly at room temperature, add physiological saline buffer solution to 1 ml, store at -4°C for later use.

[0046] 6. Use graphite and silicon wafers as the substrates of self-assembled crystals and their ultra-thin films, drip the above-mentioned 5 μL medicinal components on the graphite and silicon wafer substrates according to the L16(2)15 and L9(3)4 schemes, place -4°C for 12 hours.

Embodiment 2

[0048] Prepare the following medicinal solution according to the Pharmacopoeia specification issued by the Ministry of Health of the People's Republic of China:

[0049] 1. Preparation of Ibopridine Hydrochloride Solution 2.5 mg / 5 mL

[0050] 2. Prepare a solution containing 2 mg / 100 ml of isoproterenol hydrochloride

[0051] 3. Preparation of Physiological Salt Buffer Containing 1 mg / 2 mL Superoxide Dismutase

[0052] 4. Preparation of Physiological Salt Buffer Containing 20 mg / 3.3 mL ATP

[0053] 5. Take the solute number of each component within the concentration range of 2:3:1:2, mix evenly at room temperature, add physiological saline buffer solution to 1 ml, store at -4°C for later use.

[0054] 6. Use graphite and silicon wafers as the substrates of self-assembled crystals and their ultra-thin films, drip the above-mentioned 5 μL medicinal components on the graphite and silicon wafer substrates according to the L16(2)15 and L9(3)4 schemes, place -4°C for 12 hours.

Embodiment 3

[0056] Prepare the following medicinal solution according to the Pharmacopoeia specification issued by the Ministry of Health of the People's Republic of China:

[0057] 1. Preparation of Ibopridine Hydrochloride Solution 2.5 mg / 5 mL

[0058] 2. Prepare a solution containing 2 mg / 100 ml of isoproterenol hydrochloride

[0059] 3. Preparation of Physiological Salt Buffer Containing 1 mg / 2 mL Superoxide Dismutase

[0060] 4. Preparation of Physiological Salt Buffer Containing 20 mg / 3.3 mL ATP

[0061] 5. Take the solute number of each component within the concentration range of 0:1:1:1, mix evenly at room temperature, add physiological saline buffer solution to 1 ml, store at -4°C for later use.

[0062] 6. Use graphite and silicon wafers as substrates for self-assembled crystals and their ultra-thin films, drop 5 μL of the above medicinal components on the graphite and silicon wafer substrates according to the schemes L16(2)15 and L9(3)4, and place -4°C for 12 hours.

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Abstract

The invention provides a self-assembling light-emitting conductive nano medicinal crystal and ultra-thin film, and the preparing process, wherein non-resilient electronic tunneling interaction is employed for self-assembling oxidation resistant enzyme oxygen free radical antagonist, beta-receptor agonist, P2 receptor agonist, benzene alkylamines calcium antagonist monomer, and bibasic, ternary and quaternary compound.

Description

technical field [0001] The invention relates to the fields of photoelectric functional information materials and medicines, in particular to a self-assembled luminescent conductive nano drug crystal and an ultra-thin film and a preparation method thereof. Background technique [0002] Hypoxia is one of the important factors causing cardiopulmonary and cerebral failure, and the defense of cardiopulmonary and cerebral hypoxic damage is a hot spot in clinical research today. Modern medical research shows that cardiopulmonary and cerebrovascular β receptors, P 2 Receptor activity decreases, oxygen free radicals generate endometrial damage and increase intracellular calcium influx, which is the key to cardiopulmonary and brain damage. Aiming at the above key links, there have been studies at home and abroad using a single drug such as: iproterine, or isoproterenol, or superoxide dismutase to treat cardiopulmonary and cerebral hypoxic damage. . Nano-drug crystals are a hot rese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K38/44A61K9/70A61P9/04A61P11/00A61P25/00A61P43/00
CPCA61K31/137A61K9/14A61K9/51A61K31/52A61K38/446A61K45/06A61P9/04A61P11/00A61P25/00A61P43/00Y10S977/775
Inventor 方琰
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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