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Method for preparing monodisperse polylactic acid microsphere

A polylactic acid microsphere, monodisperse technology, applied in the field of preparation of monodisperse polylactic acid microspheres, can solve the problem of difficult to obtain microspheres with uniform size, and achieve the effect of controllable micropipe size, smooth surface and accelerated curing process

Inactive Publication Date: 2011-02-09
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the emulsification and solidification method is used to prepare microspheres of tens of microns to hundreds of microns, mechanical stirring is generally used to emulsify them to form droplets, and the droplets formed by this method have a wide particle size distribution, so it is difficult to obtain Microspheres of uniform size

Method used

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  • Method for preparing monodisperse polylactic acid microsphere
  • Method for preparing monodisperse polylactic acid microsphere
  • Method for preparing monodisperse polylactic acid microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Dissolve 0.3827g of PLA with a molecular weight of 75,000 in 5mL of dichloromethane to obtain a dispersed phase solution, weigh 1.5g of polyvinyl alcohol 124 and pour it into a flask containing 100mL of water, stir with a magnet and slowly heat to 90°C to dissolve it, and obtain continuous phase solution. Put the two solutions into 10mL glass syringes respectively, place them on two propulsion pumps, and connect them to the microchannel reactor. The microtubes with relatively large inner diameters meet, and uniformly sized droplets are continuously generated where the two phases meet. Collect the generated droplets in a beaker filled with a polyvinyl alcohol solution with a concentration of 2% (g / g), then place the beaker on a frequency conversion oscillator and shake for 2 hours, until the solvent is completely volatilized, and the droplets solidify into microspheres After that, it was washed three times with deionized water and placed in an oven at 60°C for 2 hours t...

Embodiment 2

[0026] Dissolve 0.1626g of PLA with a molecular weight of 75,000 in 5mL of dichloromethane to obtain a dispersed phase solution, weigh 1.5g of polyvinyl alcohol 124 and pour it into a flask containing 100mL of water, stir with a magnet and slowly heat to 90°C to dissolve it, and obtain continuous phase solution. Put the two solutions into 10mL glass syringes respectively, place them on two propulsion pumps, and connect them to the microchannel reactor. The microtubes with relatively large inner diameters meet, and uniformly sized droplets are continuously generated where the two phases meet. Collect the generated droplets in a beaker filled with a polyvinyl alcohol solution with a concentration of 2% (g / g), then place the beaker on a frequency conversion oscillator and shake for 2 hours, until the solvent is completely volatilized, and the droplets solidify into microspheres After that, it was washed three times with deionized water and placed in an oven at 50°C for 2 hours t...

Embodiment 3

[0029] Dissolve 0.4g of PLA with a molecular weight of 55,000 in 10mL of dichloromethane to obtain a dispersed phase solution, weigh 3g of polyvinyl alcohol 124 and pour it into a flask containing 100mL of water, stir it with a magnet and slowly heat it to 90°C to dissolve it, and obtain a continuous phase solution. Put the two solutions into 10mL glass syringes respectively, place them on two propulsion pumps, and connect them to the microchannel reactor. The thicker microtubules meet and continuously generate uniformly sized droplets where the two phases meet. Collect the generated droplets in a beaker filled with a polyvinyl alcohol solution with a concentration of 1.5% (g / g), then place the beaker on a variable frequency oscillator and shake for 3 hours, until the solvent is completely volatilized, and the droplets solidify into microspheres Finally, it was washed with deionized water for 4 times and placed in an oven at 80°C for 1 hour to obtain monodisperse PLA microsph...

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Abstract

The invention relates to a preparation method of monodisperse polylactic acid (PLA) microballoon spheres, which includes: (1) the PLA is dissolved in methylene dichloride so as to be taken as a dispersed phase and polyvinyl alcohol is dissolved in water so as to be used as a continuous phase; (2) two solutions are respectively put into injectors and the injectors are arranged on two boost pumps and connected with a microchannel reactor, and then the flow velocities of the dispersed phase and the continuous phase are adjusted to ensure that liquid drops with uniform size are continuously generated at the joint of the two phases; (3) the generated liquid drops are collected in the aqueous solution of the polyvinyl alcohol and a variable frequency oscillator is adopted to assist the volatilization of a solvent so as to ensure that the liquid drops are solidified to spheres; and (4) the spheres are washed by ionized water for a plurality of times and arranged in an oven for drying to obtain the monodisperse PLA microballoon spheres. The monodisperse PLA microballoon spheres prepared by the invention have a smooth surface and a particle size ranging from 200 Mum to 1000 Mum; a reaction device has simple and easy preparation process and controllable dimension of microchannels. The size of the prepared microballoon spheres can be conveniently adjusted and controlled and the variablefrequency oscillator is adopted for quickening the solidification process of the PLA microballoon spheres, with low cost and less time consumption.

Description

technical field [0001] The invention belongs to the field of preparation of polylactic acid microspheres, in particular to a preparation method of monodisperse polylactic acid microspheres. Background technique [0002] Polylactic acid (PLA) is the second type of polymer material approved by the US Food and Drug Administration (FDA) for use in the human body after polyglycolic acid (PGA). It has excellent biocompatibility, non-toxicity, and degradability. And the degradation products will not accumulate in vital organs. At the same time, PLA and its copolymers have good physical and chemical properties, and their strength, mechanical properties, and degradation rate can be easily adjusted by controlling the molecular weight, the composition and ratio of the copolymer, and the shape of the product can be changed from microspheres, Fiber to film, molded products, etc., so it is widely used in pharmaceutical and medical industries. [0003] PLA microspheres and microcapsules ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08L67/04
Inventor 王宏志朱丽萍朱美芳李耀刚张青红
Owner DONGHUA UNIV
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