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Tongshu oral cavity refreshing tablet and its prepn

A quality control method and a technology of traditional Chinese medicine preparations, which are applied in the direction of medical formulas, testing pharmaceutical preparations, and medical preparations containing active ingredients, etc., and can solve problems such as the decline in the content of active ingredients, the brittleness and cracking of capsule walls, and the impact on drug quality.

Inactive Publication Date: 2006-05-17
北京创立科创医药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the hard capsule shell is easy to absorb moisture and become brittle, which affects the stability of the product, and it is difficult to take the hard capsule,
[0003] In addition, Fangzhongyuan capsules contain hydrolyzed products, which are easy to deteriorate and have a short shelf life. At the same time, it also causes the content of active ingredients to decrease, thereby affecting the quality of medicines; dry and brittle cracked

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Rhubarb 100g, Citrus aurantium 100g, capillary wormwood 100g, peony bark 50g

[0051] Gentiana 100g Equisetum 100g Angelica 75g Prunella vulgaris 100g

[0052] Take the above 8 flavors, take rhubarb, peony cortex, and angelica and grind them into fine powder; add water to soak the other 5 flavors such as Gentiana japonica for 6 hours, then decoct 3 times for 1 hour each time, adding water respectively 10 times, 8 times, and 6 times. Double the amount, combine the decoction liquid, filter, and concentrate the filtrate to a thick paste with a relative density of 1.30 (50°C); mix the above fine powder with the thick paste, dry, grind into fine powder, and use 65% ethanol to make soft material, granulated with 18 mesh sieve, dried, granulated with 24 mesh sieve, added with 0.5% magnesium stearate, mixed evenly, compressed into tablets, made into 1000 tablets, coated with film, and obtained.

[0053] The film coat prescription described in tablet of the present invention is...

Embodiment 2

[0056] Rhubarb 200g Citrus aurantium 200g Capsicum chinensis 200g Moutan bark 100g

[0057] Gentiana 200g Equisetum 200g Angelica 150g Prunella vulgaris 200g

[0058] Take the above 8 flavors, take rhubarb, peony cortex, and angelica and grind them into fine powder; add water to soak the other 5 flavors such as Gentiana japonica for 6 hours, then decoct 3 times for 1 hour each time, adding water respectively 10 times, 8 times, and 6 times. Double the amount, combine the decoction liquid, filter, and concentrate the filtrate to a thick paste with a relative density of 1.30 (50°C); mix the above fine powder with the thick paste, dry, grind into fine powder, and use 65% ethanol to make soft material, granulated with 18 mesh sieve, dried, granulated with 24 mesh sieve, added with 0.5% magnesium stearate, mixed evenly, compressed into tablets, made into 1000 tablets, coated with film, and obtained.

[0059] The film coat prescription described in tablet of the present invention is...

Embodiment 3

[0062] Rhubarb 50g, Citrus aurantium 50g, Yin Chen 50g, Moutan bark 25g

[0063] Gentiana 50g Equisetum 50g Angelica 37.5g Prunella vulgaris 50g

[0064] Take the above 8 flavors, take rhubarb, peony cortex, and angelica and grind them into fine powder; add water to soak the other 5 flavors such as Gentiana japonica for 6 hours, then decoct 3 times for 1 hour each time, adding water respectively 10 times, 8 times, and 6 times. Double the amount, combine the decoction liquid, filter, and concentrate the filtrate to a thick paste with a relative density of 1.30 (50°C); mix the above fine powder with the thick paste, dry, crush into fine powder, and use 65% ethanol to make soft material, granulated with 18 mesh sieve, dried, granulated with 24 mesh sieve, added with 0.5% magnesium stearate, mixed evenly, compressed into tablets, made into 1000 tablets, coated with film, and obtained.

[0065] The film coat prescription described in tablet of the present invention is as follows ...

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Abstract

The present invention relates to Chinese medicine preparation, and is especially one kind of Tongshu oral cavity refreshing tablet and its preparation process. The tablet with the functions of clearing away heat, eliminating wetness, eliminating turbidity and relaxing the bowels is prepared with rhubarb, immature bitter orange, capillary artemisia, tree peony bark, angelica and other Chinese medicinal materials.

Description

Technical field: [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine preparation with functions of clearing away heat and dehumidification, removing turbidity and defecating. The preparation is made from traditional Chinese medicine raw materials such as rhubarb, citrus aurantium, capillary wormwood, cortex moutan 50g, Gentiana chinensis, horsetail, angelica, prunella vulgaris and the like. Background technique: [0002] Tongshukoushuang Capsules are listed in Landmark National Standard Internal Medicine Subvolume, standard number: WS-10855(ZD-0855)-2002. It has the functions of Yi medicine: Hei Bulu soil, Naiku Xi Hei; Chinese medicine: clearing heat and dehumidification, transforming turbidity and laxative. It is used to treat constipation, bad breath, and swollen gums caused by damp heat in the large intestine. Because the hard capsule shell is easy to absorb moisture and become brittle,...

Claims

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Application Information

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IPC IPC(8): A61K36/75A61K9/28A61K9/48A61P1/02A61P1/10G01N30/02G01N33/15
Inventor 和芳胡玉霞何渭清
Owner 北京创立科创医药技术开发有限公司
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