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Application of speedwell extract in preparing medicine

A technology of extract and saxifrage, applied in the field of natural plant extracts in the pharmaceutical field, can solve the problems of increasing carotid artery and cerebral blood flow in rabbits

Inactive Publication Date: 2006-05-17
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Sansevieria is the rooted whole plant of Lysimachia barystachys Bung. or Lysimachia clethroides Duby.In D.C. of Primroseaceae. The harvest season is generally July-September. Crooked mouth and eyes, poor speech and other diseases have a good curative effect. Phytochemical analysis of Sansevieria mainly contains flavonoids. Preliminary pharmacodynamics shows that its alcohol extract has a significant relaxation effect on isolated bovine cerebral artery strips , significantly increased carotid artery and cerebral blood flow in rabbits, and had obvious protective effects on acute pulmonary embolism, respiratory distress and death caused by arachidonic acid against thrombosis, but there are no reports on the pharmacology and use of Sansevieria extract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Coarsely pulverize the Sansevieria medicinal materials after cleaning;

[0035] 2. Take the above-mentioned coarsely crushed medicinal materials, add water to extract twice, add 8 times the amount each time, extract for 2 hours, and combine the first and second extracts;

[0036] 3. The extract was filtered with a membrane, and the filtrate was concentrated under reduced pressure until the specific gravity was above 1.30 (60°C), then vacuum-dried at 60°C, pulverized, and passed through a 80-mesh sieve to obtain extract powder with a yield of 6.8%;

[0037] 4. Mix 50% by weight extract powder, 30% starch, and 20% crystal cellulose, grind in a ball mill for 2 hours, pass through a 120-mesh sieve, and mix well. After passing the inspection, pack separately into the empty capsules to get the Huwei capsules for the treatment of cerebrovascular diseases.

Embodiment 2

[0039] 1. Coarsely pulverize the Sansevieria medicinal materials after cleaning;

[0040] 2. Take the above coarsely crushed medicinal materials and add 60% ethanol to heat reflux for extraction twice, add 6 times the amount of solvent each time, reflux for 2 hours each time, combine the first and second extracts to recover ethanol;

[0041]3. Add 2 times the amount of water to the extract after recovering ethanol, boil it, cool it to room temperature, filter it with a membrane, concentrate the filtrate under reduced pressure until the specific gravity is above 1.30 (60°C), then vacuum dry it at 60°C, crush it, and pass it through 80 mesh Sieve to get the extract powder, the yield is 6.2%;

[0042] 4. Mix 50% by weight extract powder and 50% starch, put it in a ball mill and grind for 2 hours, mix thoroughly, and make granules with a particle size of 40-80 mesh through dry granulation or one-step granulation machine, and dry Magnesium stearate in an amount of 0.5%-1.0% by wei...

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Abstract

The present invention relates to the new use of natural plant extract in preparing medicine, and is especially the application of speedwell extract in preparing medicine for treating cerebral apoplexy. The speedwell extract is fluid extractum or extractum powder prepared with speedwell as material and through hot water or alcohol extraction. Animal experiments show that the speedwell extract has the functions of treating cerebral ischemia of rat, protecting rat with cerebral ischemia against re-perfusion damage, increasing the narcosis CBF of dog, lowering the CVR of dog, inhibiting platelet coagulation, etc. without toxicity.

Description

technical field [0001] The invention relates to a new application of a natural plant extract in the field of pharmacy. Background technique [0002] Sansevieria is the rooted whole plant of Lysimachia barystachys Bung. or Lysimachia clethroides Duby.In D.C. of Primroseaceae. The harvest season is generally from July to September. It is effective in treating stroke and hemiplegia, numbness of limbs, Crooked mouth and eyes, poor speech and other diseases have a good curative effect. Phytochemical analysis of Sansevieria mainly contains flavonoids. Preliminary pharmacodynamics shows that its alcohol extract has a significant relaxation effect on isolated bovine cerebral artery strips , significantly increased carotid artery and cerebral blood flow in rabbits, and had a significant protective effect on acute pulmonary embolism, respiratory distress and death caused by arachidonic acid against thrombosis, but there are no reports on the pharmacology and use of Sansevieria extract...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P9/10
Inventor 万近福高崇昆张立群宾燕傅悦
Owner YUNNAN BAIYAO GROUP
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