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Freeze dried nimodipine composition and its prepn

A dry composition, nimodipine technology, applied in the field of new nimodipine freeze-dried composition and its preparation, and freeze-dried drug injection composition for injection, which can solve the problems of cumbersome preparation methods such as additives

Inactive Publication Date: 2006-05-17
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there is also a patent on the preparation method of nimodipine for injection at present, there are still deficiencies because the preparation method is cumbersome or some additives that need to be added have not yet had injection-grade standards in China.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Nimodipine 4mg

[0024] Tween 80 120mg

[0025] Macrogol 400 80mg

[0026] Glycerin 40mg

[0027] Mannitol 460mg

[0028] Water for injection to 3ml

[0029] Preparation method: Add nimodipine to Tween-80, heat at 70°C until completely dissolved, dissolve polyethylene glycol-400 and glycerin into an aqueous solution, then slowly add nimodipine Tween to the aqueous solution under stirring -80 solution, and then add excipients such as mannitol, add activated carbon at 70°C for 20 minutes, filter, freeze-dry, and pack.

Embodiment 2

[0031] Nimodipine 4mg

[0032] Tween 80 100mg

[0033] Macrogol 400 90mg

[0034] Glycerin 40mg

[0035] Mannitol 470mg

[0036] Water for injection to 3ml

[0037] See Example 1 for the preparation method.

Embodiment 3

[0039] Nimodipine 4mg

[0040] Tween 80 120mg

[0041] Macrogol 400 80mg

[0042] Glycerin 40mg

[0043] Lactose 460mg

[0044] Water for injection to 3ml

[0045] See Example 1 for the preparation method.

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PUM

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Abstract

The present invention discloses one kind of freeze dried nimodipine composition and its preparation. The freeze dried nimodipine composition consists of nimodipine, surfactant, polyglycol as solvent, excipient glycerin and mannitol, etc. The freeze dried nimodipine composition has simple preparation process, high bioavailability, excellent dissolubility and stability, and easy preservation.

Description

Technical field: [0001] The invention relates to an antihypertensive drug, in particular to a freeze-dried drug injection composition for injection. Specifically a kind of new nimodipine freeze-dried composition and its preparation method Background technique: [0002] Nimodipine is a second-generation 1,4-dihydropyridine calcium channel blocker with the molecular formula C 21 h 26 o 2 , the molecular weight is 418.45. It has anti-vasoconstriction and anti-ischemic effects on the brain. Nimodipine can prevent or eliminate various vasoactive substances (such as 5-hydroxytryptamine, prostaglandin and histamine) or blood and its degradation products. Modipine also has neurological and psychopharmacological properties. Studies on patients with acute cerebral blood supply disorders have shown that nimodipine can expand cerebral blood vessels and improve cerebral blood supply, and the increase in perfusion to brain damage and insufficient perfusion is usually greater than nor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K9/19A61P9/10A61P9/12A61P25/06
Inventor 王淑君姚慧敏
Owner SHENYANG PHARMA UNIVERSITY
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